Choline Citrate

Activated Choline (Perque) Patented Physical & Mental Performance
250ml (8.45 fl. oz.)

Choline Citrate by Perque supports Cognitive Function, improves Physical and Mental Endurance and Mood as well as general foundation of good health and well-being. Choline Citrate combines both choline and citrate. It masterfully betters cell communication, nerve impulses and liver bile detox. This patented enhanced magnesium uptake system is important in the nervous system and for the development of normal brain functioning. In addition, it helps removing fat from your liver. This aids to prevent non-alcoholic fatty liver disease (NAFLD). Choline is an essential nutrient from which adequate amounts should be included in your diet to retain optimal health. Patented enhanced magnesium uptake system when paired with PERQUE Mg Plus Guard. Those who take magnesium but still show signs of magnesium deficiency need PERQUE Choline Citrate. Cramps, muscle twitches, and spasms that persist even when magnesium is supplied indicate uptake impairment. PERQUE Choline Citrate is specifically designed to facilitate magnesium uptake for everyone. Patent number: 8,017,160. NOTE: The label of this product may vary.

£49.99 £41.66
In stock
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Ancient Purity Presents a Natural Absorbable Choline and Citrate combination, liquid supplement created by Dr Jaffe at Perque. This combination is highly important because citrate activates choline as it energises and alkalises the cell. Choline Citrate replenishes choline, stores it quickly and effectively, improving endurance and performance. Athletes, in particular, can benefit from Choline Citrate supplementation. Neurotransmitters that are dependent upon choline, such as acetylcholine, can positively affect physical performance. Studies demonstrate that exercise significantly reduces Choline levels. Studies also have indicated that Choline deficiency is linked to neurological disorders.

Perque Choline Citrate comes in a liquid form to guarantee optimum absorption and purity. The commonly used form of choline, choline bitartrate, contains corn starch and may contain reactive or irritating antigens. Perque Choline Citrate is contaminant free, more bio-available than tablets or capsules and convenient. Activated Choline has many unique benefits. Perque’s Choline Citrate has been designed specifically to deliver adequate magnesium levels for everybody. It is also essential for those taking a magnesium supplement but still show signs of magnesium deficiency. Cramps, spasms and muscle twitches which persist even with adequate magnesium intake might indicate impairment.

Choline Citrate – Information & Points to Research

  • Choline is a Must for Athletes.
  • Necessary for Proper Transport & Metabolism of Fats.
  • Can Increase Energy for Individuals who Fatigue Easily.
  • Without Choline, Fat Accumulates in the Liver.
  • Choline Citrate Increases Bile Acid Production for Gallbladder Health & Supports Weight-Loss.
  • Choline Citrate Enhances Liver Detoxification, Helping it Remove Toxic Waste Products from the Bloodstream.
  • Choline is Essential for the Transmission of Nerve Impulses.
  • Improves Memory Function.
  • Might Enhance Mood.
  • Choline Citrate Contributes to the Development of New Brain Cells.
  • Choline Citrate Might Boost Mental Energy.
perque UK

Perque's Unique Choline Citrate

Perque Choline Citrate can increase magnesium uptake. No other form of choline has this benefit. This unique supplement is essential for people who have a block in the primary calcium-magnesium ATPase uptake system, such as individuals with chronic fatigue syndrome or fibromyalgia. This is the pathway that creates energy and takes magnesium into cells. The caveat is that the pathway requires adequate energy to work efficiently. About 30% of the dietary magnesium is absorbed, mainly in the small intestine with a smaller contribution in the colon.

When stress or illness compromises the immune system, and when diet, toxins, or immune reactions cause excess cellular acidity (metabolic acidosis), magnesium uptake cannot take place, and this important pathway is impaired. Bypassing the energy pathway, Perque Choline Citrate and Perque Mg Plus Guard together create a neutral charge to carry magnesium effortlessly through the cell membrane. Like we explained before, people who take magnesium but still show signs of magnesium deficiency need Perque Choline Citrate. Cramps, muscle twitches, and spasms that persist even when magnesium is supplied indicate uptake impairment. We need Magnesium as it plays many vital roles in our bodies, such as promoting nerve and muscle function and energy production. One of the first symptoms of magnesium deficiency is often chronic tiredness. You might notice muscle spasms, stiffness and weakness as well. Nausea and loss of appetite and are other common signs in the beginning stages. However, in the beginning you might not notice any symptoms at all.

Choline Citrate an Activated Formula

perque Choline Citrate UK

Choline Functions

Choline is not actually a vitamin or mineral, it's an organic water-soluble compound that's often grouped with B vitamins, because it has similar properties and functions. It helps in regulation of many body functions.

Fat Transport & Metabolism... Choline is necessary for turning fat and cholesterol into lipoproteins called very low density lipoproteins (VLDL). It also helps transport VLDL into the bloodstream and to the extrahepatic (Situated outside the liver) tissues, preventing fat and cholesterol from accumulating in the liver. A small 2014 research indicated that female athletes who took a choline dietary supplement had lower body mass indexes (BMIs) and leptin levels than the control group. High leptin levels tell your brain that you’ve plenty of fat stored, while low leptin levels tell your brain that you’ve low fat stores and that you need to eat. 

DNA Synthesis... According to a study published in the journal Mutation Research, choline is a major source of methyl groups necessary for the synthesis of S-adenosylmethionine (Also known as SAMe), which is needed for epigenetic marking of DNA and histones.

Nervous System Function…Choline is a precursor for acetylcholine, a neurotransmitter involved in various neuronal functions, including muscle control, circadian rhythm and memory. In other words, your body transform choline into a neurotransmitter which affects your nerves and plays a role in regulating automatic bodily functions, such as heart rate and breathing.

Cell Structure... Choline is necessary for the synthesis of phosphatidylcholine and sphingomyelin, which are phospholipids that help maintain the structural integrity of the cell membranes. As a critical component of the cell membrane, Choline ensures the cell’s structural integrity and signaling functions. Choline is also used for neurotransmission (as the metabolite, acetylcholine), is a main source of methyl donors, and is need for lipid transportation from the liver.

Cell Messaging... The phospholipids that are synthesised from choline also act as a precursor for the intracellular messenger molecules, diacylglycerol and ceramide.

Take the Time to Think of Choline

choline preque ancient purity

Choline Citrate Gives

Improvement of Cystic Fibrosis Symptoms… One 2018 research indicated that choline supplementation enhanced lung function and decreased fatty liver disease symptoms in 10 participating adult men with cystic fibrosis.

Reducing Pregnancy Complications… Choline can affect foetal development and might influence pregnancy outcomes. In one 2013 scientific research, for example, females in their 3rd pregnancy trimester were given either 480 mg or 930 mg of choline daily. Those women who consumed higher doses had decreased preeclampsia markers. Preeclampsia signs include severe headaches, high blood pressure, and swelling. So, we can conclude that Choline is especially important during pregnancy, as a low intake may raise the risk of neural tube defects in unborn babies.

Promotes Heart Health… A 2018 scientific study revealed a link between an increased dietary consumption of choline and a reduced risk of ischemic stroke. The study observed at almost 4,000 participating African Americans, with an average 9 year follow-up period.

Body & Mind... In a recent study, researchers examined random, placebo-controlled trials of choline deficiency in cognitive disorders. The reviewers found that choline had significant beneficial effects on memory function and behaviour. In another study, researchers found that choline supplementation improved subjects’ memory, especially in Alzheimer’s patients. Choline helps the body as well as the mind. Studies show that in trained athletes, physical exertion can deplete choline stores by as much as 40%. In one such study, researchers concluded that “Thus, the reductions in plasma choline associated with strenuous exercise may reduce acetylcholine release, and could thereby affect endurance or performance.”

Choline Citrate... A Natural Solution

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Are you Deficient in Choline Citrate?

While your liver produces some Choline, it’s not enough to meet your body’s needs and prevent a deficiency. You must get Choline from your diet. The amount of Choline you need depends on many factors, such as your age and gender, but several groups are at especially high risk for Choline deficiency, including: those eating a diet high in healthy saturated fats, vegetarians and vegans (The best sources of dietary choline are animal foods), postmenopausal women, people who drink a lot of alcohol, endurance athletes (Marathons and triathlons can deplete Choline levels), pregnant and lactating women. Some individuals have genetic variances, or polymorphisms, that can increase their need for choline. Certain ethnic and racial groups are more likely to be included in this group. In Ancient Purity's opinion, the fact that this Choline Supplement as well as our animal food source Herring Caviar Oil (See our ‘Related Products’ page) can provide you with a dependable source of supplemental Choline makes either product invaluable for not just those at increased risk but for everyone.

Choline deficiency can cause harm, especially for your liver. One research in 57 adults revealed that 77% of males, 80% of postmenopausal females and 44% of premenopausal females experienced muscle and/or liver damage after having followed a Choline-deficient diet. You can read the scientific study on Choline and Liver Health here. Another recent research revealed that when postmenopausal females followed a diet with limited Choline, 73% experienced muscle or liver issues. However, these damages disappeared once they began consuming adequate amounts of Choline. One study indicated that an increased dietary intake around conception time was associated with a reduced risk of neural tube issues. In addition, low Choline intake might increase your chance of experiencing other pregnancy complications such as low birth weight, preeclampsia and premature birth. It is known that most people in the USA do not get adequate quantities in their diets!

Choline Citrate by Perque Supplied by Ancient Purity

Choline is not actually a vitamin or mineral, it's an organic water-soluble compound that's often grouped with B vitamins, because it has similar properties and functions. It helps in regulation of many body functions.

Choline Citrate under Study during Pregnancy

Studies have underscored the importance of Choline during pregnancy. During pregnancy, the mother provides high amounts of Choline across the placenta to the foetus. The effect of this nutrient on foetal brain development occurs during embryonic days 11 - 17. Studies have shown that higher dietary Choline intake during this sensitive window in foetal development may lead to enhanced memory performance in later life. Choline is also responsible for improving the signaling mechanisms involved in the formation of new blood vessels in the placenta. Plus, it may help inhibit the pathological precursors of preeclampsia, as well as mitigate the effects of alcohol exposure to the foetus.

Moreover, Choline deficiency during pregnancy may put the baby at risk of neural tube defect and orofacial cleft (The lip or the roof of the mouth does not form the usual way). In the USA, pregnant women who consume only 150mg of Choline daily are 4 times more likely to have a baby with neural tube defects, while their risk for having a baby with orofacial cleft increases by up to 1.7%. 

“You are pregnant and you are powerful. You are bold and you are beautiful. Go forward in your boldness, in your beauty and in your contentedness. Trust your body to birth and know that the collective power of women worldwide will be with you.” - Author Unknown

Choline Supports Healthy Pregnancy

Choline deficiency during pregnancy may put the baby at risk of neural tube defect and orofacial cleft (The lip or the roof of the mouth does not form the usual way). In the USA, pregnant women who consume only 150mg of Choline daily are 4 times more likely to have a baby with neural tube defects, while their risk for having a baby with orofacial cleft increases by up to 1.7%.

Choline Scientific Evidence

The significance of ensuring sufficient Choline intakes during pregnancy is increasingly recognised. Plenty of scientific research has proved that Choline is crucial for a range of of physiological processes during the prenatal period playing roles in membrane biosynthesis and tissue expansion, neurotransmission and brain development, and methyl group donation and gene expression. Studies in humans and animals have indicated that supplementing the maternal diet with additional Choline improves several pregnancy outcomes and protects against certain metabolic and neural insults.

Most pregnant women in the U.S.A are not achieving Choline intake recommendations of 450 mg daily and would most-likely benefit from increasing their choline intakes via their diets or high-quality supplemental approaches. Choline is found in both animal and plant source foods; however, animal source foods typically contain more choline per gram of food product. Beef, eggs, chicken, fish, and pork are concentrated sources of choline providing more than 60 mg per 100 g. Among plant source foods, nuts, legumes, and cruciferous vegetables such as broccoli are relatively good sources providing at least 25 mg per 100 g. Although not a concentrated source, cow’s milk is a main contributor to dietary Choline intake in the U.S.A. 

Perque Choline Citrate - Naturally Supportive

Perque Choline Citrate comes in a liquid form to guarantee optimum absorption and purity. The commonly used form of choline, choline bitartrate, contains corn starch and may contain reactive or irritating antigens. Perque Choline Citrate is contaminant free, more bio-available than tablets or capsules and convenient. Activated Choline has many unique benefits. Perque’s Choline Citrate has been designed specifically to deliver adequate magnesium levels for everybody. It is also essential for those taking a magnesium supplement but still show signs of magnesium deficiency. Cramps, spasms and muscle twitches which persist even with adequate magnesium intake might indicate impairment.

Choline Citrate…Closing Thoughts

Choline Citrate is Choline combined with citrate which is an ester of citric acid. Binding Choline to citrate contributes to the synthesis of acetylcholine (ACh) in your brain. The two precursors required for acetylcholine (ACh) synthesis are Choline (2-hydroxy-N,N,N-trimethyl-ethanaminium) and the enzyme acetyl-Coenzyme A (Acetyl-CoA). Citrate is the source of about one third of the acetyl groups used for the synthesis of ACh. Your brain uses acetylcholine to maintain clear communication. In fact, it’s used to maintain communication between all the cells in your body. 

And you need Choline for cognition, memory, sleep and even maintaining your balance, stability and mobility. Your brain needs Choline to function. When choline is in short supply, your brain goes on a scavenger hunt and starts to steal Choline from nerve cell membranes. In your brain’s attempt to maintain normal acetylcholine signaling, it starts taking cells apart. This works in the short term. Your brain uses this technique to keep your memory and other functions running smoothly. But in the long run it takes a toll on your brain at the cellular level. This is the primary reason you need to add Perque’s Choline Citrate supplement to your diet.

Experience Perque's Unique Choline Citrate - Order Today

perque UK choline Citrate
  • Choline Citrate.
  • Glycerine (vegetable).

Other Ingredients: None.

  • As a dietary supplement‚ take one (1) teaspoon in juice or water or as directed by your health professional. Do not exceed the recommended daily intake.
  • Brand: Perque.
  • Form: Liquid.
  • Quantity: 250ml (8.45 fl. oz.).
  • Container: Glass bottle.
  • Storage: Keep in a cool dry place, keep out of reach of children.
  • Estimated shelf life from purchase: 1 - 2 years.

Scientific Articles

NCBI Resources - Choline: An Essential Nutrient for Public Health

MDPI - Special Issue "Choline: An Essential Nutrient for Human Health"

Oxford Academic – Advances in Nutrition Choline

Frontiers in Nutrition - Food Sources Contributing to Intake of Choline and Individual Choline Forms in a Norwegian Cohort of Patients with Stable Angina Pectoris

Europe PMC - Choline: Dietary Requirements and Role in Brain Development.

Supporting Scientific Research

  1. 1.Fioravanti M, Yanagi M: Cytidinediphosphicholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Chochrane Database Syst. Rev 2005 Apr 18; (2):CD000269. 2.Canty DJ, Zeisel SH: Lecithin and choline in human health and disease. Nutr Reviews 1994; 52: 327- 339.
  2. 3. Zeisel SH. Choline: needed for normal development of memory. J Am Coll Nutr 2000 Oct; 19 (5 Suppl):528S-531S.
  3. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr 2006;26:229-50. 5. Spector SA, Jackman MR, Sabounjian LA, Sakas C, Landers DM, Willis VVT: E ect of choline supplementation on fatigue in trained cyclists. Med Sci Sports Exerc 1995 May; 27(5): 668-73.
  4. Conlay LA, Sabounjian LA, Wurtman RJ: Exercise and neuromodulators: choline and acetylcholine in marathon runners. Int J Sports Med 1992 Oct; 13 Suppl 1:S141-2.
  5. Secades JJ, Lorenzo JL. Citicoline: Pharmacological and clinical review, 2006 update. Methods Find Exp. Clin Pharmacol. 2006 Sep;28 Suppl B:1-56.
  6. Penry J, Manore M. Choline: an important micronutirent for maximal endurance-exercise performance? Int J Sport Nutr Exerc Metab. 2008;18:191–203.
  7. Shaw G, Carmichael S, Yang W, Selvin S, Schaffer D. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol. 2004;160:102–109.
  8. Fischer L, da Costa K, Kwock L, Stewart P, Lu T, Stabler S, Allen R, Zeisel S. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007;85:1275–1285.
  9. Zeisel S. Perinatal choline influences brain structure and function. Nutr Rev. 2006;64:197–203.
  10. Fisher M, Zeisel S, Mar M, Sadler T. Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology. 2001;64:114–122.
  11. da Costa KA, Gaffney C, Fischer L, Zeisel S. Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr. 2005;81:440–444.
  12. Detopoulou P, Panaglotakos B, Antonopoulou S, Pittsavos C, Stefanadis C. Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in health adults: the ATTICA study. Am J Clin Nutr. 2008;87:424–430.

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