Vitamin B12 (Activated)™

Vegan / Energy (Perque) Hydroxocobalamin with Magnesium
100 Lozenges

Perque’s superior Vitamin B12 lozenges might improve mental clarity and sharpness by maintaining healthier cognitive function and brain and gut neuro chemicals. Vitamin B12 is essential for proper function of the nerves and the brain, and for the production of red blood cells. It also significantly improves the production of energy, endurance and beats chronic tiredness and weakness. This cutting-edge supplement comes in preferred hydroxocobalamin form, proven most absorbable and easily converted form of B12. It just takes one daily lozenge to feel revitalised, vigorous and energised again!. Perque's B12 "Oral Injection" for Energy and Detox... Perque Activated B-12 Guard is made in lozenge form for maximum uptake and optimal delivery to the brain. Studies on Perque Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injections. Easy use, just take 1 daily Sublingual Lozenge.

£39.99 £33.32
In stock
EU/World Prices

Ancient Purity proudly presents a powerful Vitamin B12 option. Perque's B12 "Oral Injection" for Energy and Detox... Perque Activated B-12 Guard is made in lozenge form for maximum uptake and optimal delivery to the brain. Studies on Perque Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injections. Patients notice that they feel better more quickly. Vitamin B-12 in our food supply is estimated to be 78% less than in the 1960s. Diet alone is hard-pressed to provide the necessary levels of this important nutrient. In addition, stress and reduced hydrochloric acid (HCl) and intrinsic factor production in the stomach impair absorption. The most commonly used forms of B-12 require activation in the body, making uptake quite low, rarely more than 50%.

Perque delivers Vitamin B-12 in its superior, activated hydroxocobalamin form. Although it is not cheap and difficult to obtain, hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms. For this reason, it is the only form Perque provides. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence. Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosyl-cobalamin as needed in the body. Hydroxocobalamin, the parent to other B-12 forms, provides better, long-lived B-12 action in the body.

Activated Vitamin B12 - Information & Points to Research

  • Improves Energy & Endurance.
  • Easy, Just Take 1 Daily Sublingual Lozenge.
  • Created by Dr Jaffe.
  • Improves Mental Clarity.
  • Hydroxocobalamin Absorbable & Easily Converted Activated Form.
  • Essential for Vegans.
  • Likely a Carnivores’ Game Changer.
  • DNA & Protein Synthesis.
  • Trusted Formula from Perque.
  • Activated Hydroxocobalamin Form.
  • Optimal Absorption.
  • Helps to Remove Toxins from the Body & Improve Brain and Nerve Cell Function. 
PERQUEsupplementation vitamin b12

Perque Activated B12 for S-Adenosylmethionine (SAMe)

Optimal absorption of vitamin B-12 is essential to keep SAMe (S-adenosyl methionine) in its beneficial form. SAMe is critical for the manufacture of brain chemicals and for detoxification. It might also be helpful reducing chronic low mood symptoms and joint issues. SAMe is a molecule which is naturally formed in our bodies. It can be created in the laboratory as well. SAMe is involved in the activation, formation, and breakdown of other bodily chemicals, such as proteins, hormones, and certain drugs. Our bodies use SAMe for the production of certain bodily chemicals that play a role in discomfort, low mood, liver illness, and other conditions. These activated B-12 lozenges by Perque deliver B-12 in its superior‚ hydroxocobalamin (Manufactured version of the vitamin B12) activated form.

This form is superior because it has the highest half-life of any other form that has been shown to raise B-12 serum levels. It is very effective in preventing low Vitamin B Levels (Vitamin B12 deficiency) as well as anaemia. Perque designed this product to help remove toxins from the body and improve brain and nerve cell function. B-12 supplementation can stimulate the way the body uses fats‚ proteins and carbohydrates‚ which can result in increased energy. Since our bodies don’t produce Vitamin B12, we have to obtain it from animal-based foods or from quality health supplements. And we need to do that on a frequent basis, because our bodies do not store Vitamin B12 for a long period of time. Perque’s Vitamin B12 supplement doesn’t contain citrus, MSG, wheat, gluten, corn, starch, sugar, soy, yeast, sulphates, phosphates (other than Coenzyme), preservatives, casein or other milk derivatives. 

A Superior Sublingual B12 from Perque

Maintain Normal Homocysteine Levels... Beat Exhaustion with Vitamin B12

The importance of maintaining normal homocysteine levels cannot be overemphasised. Your heart health depends on it. Clearly, the scientific evidence indicates that nutrient deficiency is a factor in elevated homocysteine levels. However, in a recent study, researchers discovered that in many patients, even when serum levels of vitamins appear to be normal, homocysteine concentrations were still too high. Elevated homocysteine levels are implicated in much more than heart disease. In a study of women with both chronic tiredness and aches in every part of their bodies, researchers discovered that all of the patients had high levels of homocysteine in their cerebrospinal fluid.

Nearly all homocysteine transforms to other proteins. If you have an amount more than 50 mcmol/L, the excess homocysteine might harm the lining of your arteries (Blood vessels that carry oxygen-rich blood throughout our bodies) as well. They also noted a significant correlation between high homocysteine levels and fatigue (chronic tiredness and weakness). The study emphasised the importance of the relationship between B-12 and homocysteine and showed that B-12 deficiency was a contributing factor. By decreasing levels of homocysteine in the central nervous system, B-12 can help prevent and treat fatigue. If you're feeling tired or weak, taking Perque’s Vitamin B12 might give you an energy boost and stimulate your metabolism.

Scientifically Effective Vitamin B12

PERQUEsupplementation b12

About Vitamin B12

Vitamin B12, also known as cobalamin is a water-soluble vitamin that can be found in various foods‚ including shellfish‚ eggs‚ meat and dairy products. Water-soluble vitamins can dissolve in water and travel through our bloodstream. It plays a vital role in DNA, nerve tissue health, brain function, red blood cells production and protein synthesis. Nutritional deficiency is believed to be rare because the body stores several years’ worth of this vitamin in the liver; however‚ many people who have a B12 deficiency have trouble absorbing the vitamin. This is actually quite a common problem in the ageing population. It is also of concern for those who have HIV or other immune deficiencies‚ and for those who do not eat meat (Vitamin B-12 is naturally available in meats) and/or dairy (Vegetarians and vegans). Truly‚ it is unknown exactly how common this deficiency is in the UK population‚ but it is well documented that adults over 65 years of age are more likely to be deficient than younger people. In the United States, between 1.5% and 15% of the population are currently diagnosed with vitamin B-12 deficiency.  Vitamin B12 plays an important role in DNA synthesis and neurologic function.

Vitamin B12 deficiency…happens when our bodies do not obtain enough vitamin B12. This might lead irreversible and potentially serious damage, particularly to the brain and nervous system. Even slightly lower-than-normal vitamin B12 levels can trigger deficiency signs, such as feeling low, confusion, memory issues, and tiredness. However, these symptoms alone aren’t specific enough to diagnose Vitamin B12 deficiency. Other Vitamin B12 deficiency symptoms include constipation, loss of appetite, and weight-loss. Once symptoms get worse, they can lead to neurological changes, such as numbness and tingling in feet and hands. Some persons might find it hard to maintain their balance. Infants who not have enough Vitamin B12 might show unusual movements, such as tremors in the face, as well as reflex issues, feeding problems, irritation, and eventual growth conditions if this vitamin deficiency is left untreated. Vitamin B12 deficiency carries a severe risk of permanent brain and nerve damage. Some persons with inadequate vitamin B12 levels have an increased risk of developing psychosis, dementia and mania.

Activated B12 for an Active Lifestyle

PERQUEsupplementation UK activated Vitamin B12

Symptoms of B12 Deficiency

If you only have a mild deficiency‚ you might not have any symptoms at all or they might be so mild that you won’t notice them. This is exactly why it is important to get a blood test to find out if you have appropriate levels of Vitamin B12 in your blood. However‚ as the deficiency increases‚ you may begin to feel tired‚ weak and lightheaded. Your gums may bleed‚ and your tongue may be red and sore. You might often feel nauseous and you might start losing a good deal of weight. Others may notice your pale skin. You could begin to suffer from bowel-related problems like diarrhoea or constipation‚ and you might feel sick to your stomach and lose weight. 

''I'm very conscious about putting good food into my body. Years ago, I went to see an amazing healer called Allahi, who could read your body. She told me that I can't absorb vitamins very well, and I have to eat the right things to get my vitamins. I've always remembered that.'' - Author: Trinny Woodall

It is so crucial to maintain adequate levels of Vitamin B12‚ as with the activated form in Perque’s B12‚ because an advanced deficiency can cause even more severe problems. If you suffer from extremely low serum levels of Vitamin B12‚ you might start to feel numbness and tingling in your extremities‚ a loss of coordination and motor skills‚ low mood and eventually memory loss‚ which can lead to a complete loss of mental abilities. Fortunately‚ it is easy to maintain adequate Vitamin B12 levels with supplementation‚ so you can avoid any of these symptoms. If you have trouble absorbing Vitamin B12‚ visit your doctor so he or she may closely monitor your levels during the course of supplementation. Don’t forget to tell your doctor about Perque Activated Vitamin B12 Guard. I’m sure, just like Ancient Purity, your doctor will recommend it!

Awaken with Activated B12

Perque’s superior Vitamin B12 lozenges might improve mental clarity and sharpness by maintaining healthier cognitive function and brain and gut neuro chemicals. Vitamin B12 is essential for proper function of the nerves and the brain, and for the production of red blood cells. It also significantly improves the production of energy, endurance and beats chronic tiredness and weakness. This cutting-edge supplement comes in preferred hydroxocobalamin form, proven most absorbable and easily converted form of B12. It just takes one daily lozenge to feel revitalised, vigorous and energised again

About Perque & Dr Jaffe

The roots of Perque Integrative Health, LLC (PIH) are embedded in the history and works of the scientist who founded the company and who has remained, with the support of dedicated staff, at its helm for over 30 years. Dr. Russell M. Jaffe, CEO and Chairman of PIH worked at the National Institutes of Health from 1973 to 1979 where the seeds of his vision began. On leaving NIH Dr. Jaffe began a journey that sought to support the emerging field of Integrative and Regenerative Medicine. His dedication to the application of primary prevention and his commitment to providing superior nutraceuticals and autoimmune testing with clinical evidence of superior efficacy has made him a sought after speaker and leader in his chosen field. Dr. Jaffe and his team have steadily moved forward and produced a volume of evidence-based work that has profoundly enhanced functional human nutrition, integrative medicine and proactive preventive healthcare models.

  • Scientifically... Every part of PIH is backed by an extraordinary level of scientific superiority and efficacy. Exceptional evidence-based science is the foundation for every innovative idea, technology, and theory that PIH uses to create and design its superior products, programs and services.
  • Healthful The motivation that drives PIH is a healthier world. Good health-mental, physical and emotional – is the unsung hero of happiness. It’s what allows us to feel motivated, strong and inspired. At PIH, everything we do is to promote and encourage a healthier world, ensuring better lives for the generations of today and tomorrow. Healthy living isn’t just our philosophy, it’s our way of life!
  • Pioneering At PIH, breaking new ground is the status quo. We have blazed the trail for almost every path we’ve ever travelled. Identifying the flaws and weaknesses of commonly accepted axioms is our strength and its what’s allowed PIH to define new means, new norms – new ways of thinking. At times we’ve been considered revolutionary and even controversial, but like all pioneers, we bring the fight before the fight is won.
  • Sustainable At PIH we know good health –  good living – is a long term commitment. To be truly healthy, we must accept and devote ourselves to lifestyle changes, not quick fix pill-popping. And while these changes feel daunting at first, with PIH as a partner for life, daunting changes quickly give way to optimal health and vitality no pill can match. This is why our integrative solutions to health are designed with long term impact in mind so that we move beyond suppressing symptoms and instead, resolve the truer ailments that cause them.

Vitamin B12 - Essential Energy Booster

rVitamin B12 lozenges PERQUE supplementation UK

Vitamin B12 (Activated)™… Closing Thoughts

Do you get sufficient vitamin B12 amounts? You really want to make sure that you do, so you’ll remain good health? Vitamin B12 does a lot of good things for your precious body. It aids create your DNA and red blood cells, for example. Unfortunately your body cannot make Vitamin B12. Normally you can get B12 from animal-based foods or from dietary supplements. And it is important to take or get Vitamin B12 regularly, because your body stores Vitamin B12 for a short time only. If you are not sure, you can ask your health care practitioner if you could get a blood test checking your Vitamin B12 levels. As we get older, it can become more difficult to absorb this essential vitamin. It can also happen if you’ve had weight-loss surgery or another medical operation that removed a part of your stomach, or if you’re a heavy drinker. You can get Vitamin B12 deficiency if you follow a vegan diet (Not consuming any animal products, including eggs, milk, meat, milk, and cheese) or if you are a vegetarian not eating enough eggs or dairy products to require your vitamin B12 demands. In both cases, you can include fortified foods to your diet or take Ancient Purity’s supplement by Perque to meet this need.

The following proven health benefits of Vitamin B12 are based on scientific research, these include: helps with red blood cell formation and anaemia Prevention, help prevent major birth defects, might support bone health, lower risk of homocysteine levels, macular degeneration, and improve overall emotional well-being. 

"I got cocky and I stopped taking my vitamins. It was an inconvenience to have a suitcase full of vitamins with me on the road. About two years ago, it caught up with me.'' - Author: Mary Ann Mobley

Experience Perque's Activated Vitamin B12 Benefits - Order Today

best vitamin b12 for vegans
  • B-12 (hydroxocobalamin) - 2000 mcg.
  • Magnesium (C16, C18 alkyls) from whole untreated palm fruit  - 3.5 mg.
  • Phosphatidylethanolamine - 295 mg.
  • As a dietary supplement‚ take one (1) sublingual lozenge daily or as directed by your health professional. Place one lozenge under tongue and let dissolve. Do not exceed the recommended daily intake.

NOTE: Pregnant and nursing mothers need to check with their health professional before taking supplements.

  • Brand: Perque.
  • Form: Lozenges.
  • Quantity: 100.
  • Container: Glass bottle.
  • Storage: Keep in a cool dry place, keep out of reach of children.
  • Estimated shelf life from purchase: 1 - 2 years.

Scientific Articles

MDPI - Vitamin B12 in Health and Disease

American Family Physician - Vitamin B12 Deficiency: Recognition and Management

the bmj - Investigating vitamin B12 deficiency

Supporting Scientific Research

  1. Albert C.M., Cook N.R., Gaziano J.M., Zaharris E., MacFadyen J., Danielson E., Buring J.E., Manson J.E. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA. 2008;299:2027–2036.
  2. Potter K., Hankey G.J., Green D.J., Eikelboom J., Jamrozik K., Arnolda L.F. The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis. BMC Cardiovasc. Disord. 2008;8:24.
  3. Ray J.G., Wyatt P.R., Thompson M.D., Vermeulen M.J., Meier C., Wong P.-Y., Farrell S.A., Cole D.E. Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology. 2007;18:362–366.
  4. Allen L.H. How common is vitamin B-12 deficiency? Am. J. Clin. Nutr. 2009;89:693–696. doi: 10.3945/ajcn.2008.26947A.
  5. Scott J.M. Bioavailability of vitamin B12. Eur. J. Clin. Nutr. 1997;51:S49–53.
  6. Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. J Am Med Assoc 2013;310:2435–42.
  7. Sviri S, Khalaila R, Daher S, et al. Increased vitamin B12 levels are associated with mortality in critically ill medical patients. Clin Nutr 2012;31:53–9.


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