Vitamin B12 (Activated)™

Vegan / Energy (Perque) Hydroxocobalamin
100 Lozenges
Improves mental clarity and sharpness by maintaining healthier SAMe brain and gut neuro chemicals. Significantly improves energy, endurance and beats fatigue. Preferred hydroxocobalamin form, proven most absorbable and easily converted form of B12.
£39.99 £33.32
In stock
EU/World Prices

Perque B12 "Oral Injection" for Energy and Detox... PERQUE Activated B-12 Guard is in lozenge form for maximum uptake and optimal delivery to the brain. Studies on PERQUE Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injection. Patients notice that they feel better more quickly. Vitamin B-12 in our food supply is estimated to be 78% less than in the 1960s. Diet alone is hard-pressed to provide the necessary levels of this important nutrient. In addition, stress and reduced hydrochloric acid (HCl) and intrinsic factor production in the stomach impair absorption. The most commonly used forms of B-12 require activation in the body, making uptake quite low – rarely more than 50%.

PERQUE delivers Vitamin B-12 in its superior, activated hydroxocobalamin form. Although it is more expensive and difficult to obtain, hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms. For this reason, it is the only form PERQUE uses. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence. Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosyl-cobalamin as needed in the body. Hydroxocobalamin, the parent to other B-12 forms, provides better, long-lived B-12 action in the body.

Activated Vitamin B12

  • Improves energy and endurance.
  • Easy daily sublingual lozenge.
  • Improves mental clarity.
  • Hydroxocobalamin absorbable and easily converted activated form.
  • Essential for Vegans.
  • Likely a game changer for canivores.
  • DNA and protein synthesis.
  • Trusted Formula from Perque.
PERQUEsupplementation vitamin b12

Perque Activated B12 for SAMe

Optimal absorption of vitamin B-12 is essential to keep SAMe (S-adenosyl methionine) in its beneficial form. SAMe is critical for the manufacture of brain chemicals and for detoxification.

These activated B-12 lozenges by Perque deliver B-12 in its superior‚ hydroxocobalamin activated form. This form is superior because it has the highest half-life of any other form that has been shown to raise B-12 serum levels.

Perque designed this product to help remove toxins from the body and improve brain and nerve cell function. B-12 supplementation can stimulate the way the body uses fats‚ proteins and carbohydrates‚ which can result in increased energy. 

Essential Energy

Vitamin B12 lozenges PERQUE supplementation UK

Homocysteine... Beat Fatigue with Vitamin B12

The importance of maintaining normal homocysteine levels cannot be overemphasized. Your heart health depends on it. Clearly, the scientific evidence indicates that nutrient deficiency is a factor in elevated homocysteine levels. However, in a recent study, researchers discovered that in many patients, even when serum levels of vitamins appear to be normal, homocysteine concentrations were still too high.

Elevated homocysteine levels are implicated in much more than heart disease. In a study of women with both chronic fatigue and fibromyalgia, researchers discovered that all of the patients had high levels of homocysteine in their cerebrospinal fluid.

They also noted a significant correlation between high homocysteine levels and fatigue. The study emphasized the importance of the relationship between B-12 and homocysteine and showed that B-12 deficiency was a contributing factor. By decreasing levels of homocysteine in the central nervous system, B-12 can help prevent and treat fatigue.

Scientifically Effective

PERQUEsupplementation b12

About Vitamin B12

Vitamin B12 is a water-soluble vitamin that can be found in various foods‚ including shellfish‚ eggs‚ meat and dairy products. It plays a vital role in DNA and protein synthesis. Nutritional deficiency is believed to be rare because the body stores several years’ worth of this vitamin in the liver; however‚ many people who have a B12 deficiency have trouble absorbing the vitamin.

This is actually quite a common problem in the ageing population. It is also of concern for those who have HIV or other immune deficiencies‚ and for those who do not eat meat and/or dairy (vegetarians and vegans). 

Truly‚ it is unknown exactly how common this deficiency is in the population‚ but it is well documented that adults over 65 years of age are more likely to be deficient than younger people. Vitamin B12 plays an important role in DNA synthesis and neurologic function.

Deficiency can lead to a wide spectrum of hematologic and neuropsychiatric disorders that can often be reversed by early diagnosis and prompt treatment. 

Activated B12 for an Active Lifestyle

PERQUEsupplementation UK activated Vitamin B12

Scientific Evidence

perque digesta guard

1. Glueck CJ, et al.: Evidence that homocys- teine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am J Cardiol 1995 Jan 15; 75: 132-136.

2. Andres E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blickle JF.VitaminB12 (cobalamin) deficiency in elderlypatients. CMAJ 2004 Aug 3;171(3):251-9.

3. Abalan F, Subra G. Picard M, Boueilh P. Incidence of vitamin B-12 and folic acid in patients admitted to a geriatric psychiatry unit. [Article in French] Encephale 1984; 10: 9-12.


Symptoms of B12 Deficiency

If you only have a mild deficiency‚ you might not have any symptoms at all or they might be so mild that you won’t notice them. This is exactly why it is important to get a blood test to find out if you have appropriate levels of B12 in your blood.

However‚ as the deficiency increases‚ you may begin to feel tired‚ weak and lightheaded. Your gums may bleed‚ and your tongue may be red and sore. You might often feel nauseous and you might start losing a good deal of weight. Others may notice your pale skin. You could begin to suffer from bowel-related problems like diarrhoea or constipation‚ and you might feel sick to your stomach and lose weight. 

It is so crucial to maintain adequate levels of B12‚ as with the activated form in Perque’s B12‚ because an advanced deficiency can cause even more severe problems. If you suffer from extremely low serum levels of vitamin B12‚ you might start to feel numbness and tingling in your extremities‚ a loss of coordination and motor skills‚ depression and eventually dementia‚ which can lead to a complete loss of mental abilities. 

Fortunately‚ it is easy to maintain adequate B12 levels with supplementation‚ so you can avoid any of these symptoms. If you have trouble absorbing B12‚ visit your doctor so he or she may closely monitor your levels during the course of supplementation.

About Perque and Dr Jaffe

The roots of PERQUE Integrative Health, LLC (PIH) are embedded in the history and works of the scientist who founded the company and who has remained, with the support of dedicated staff, at its helm for over 30 years. Dr. Russell M. Jaffe, CEO and Chairman of PIH worked at the National Institutes of Health (NIH) from 1973 to 1979 where the seeds of his vision began. On leaving NIH Dr. Jaffe began a journey that sought to support the emerging field of Integrative and Regenerative Medicine. His dedication to the application of primary prevention and his commitment to providing superior nutraceuticals and autoimmune testing with clinical evidence of superior efficacy has made him a sought after speaker and leader in his chosen field. 

Dr. Jaffe and his team have steadily moved forward and produced a volume of evidence-based work that has profoundly enhanced functional human nutrition, integrative medicine and proactive preventive healthcare models.

  • Scientific Every part of PIH is backed by an extraordinary level of scientific superiority and efficacy. Exceptional evidence-based science is the foundation for every innovative idea, technology, and theory that PIH uses to create and design its superior products, programs and services.
  • Healthful The motivation that drives PIH is a healthier world. Good health-mental, physical and emotional – is the unsung hero of happiness. It’s what allows us to feel motivated, strong and inspired. At PIH, everything we do is to promote and encourage a healthier world, ensuring better lives for the generations of today and tomorrow. Healthy living isn’t just our philosophy, it’s our way of life!
  • Pioneering At PIH, breaking new ground is the status quo. We have blazed the trail for almost every path we’ve ever traveled. Identifying the flaws and weaknesses of commonly accepted axioms is our strength and its what’s allowed PIH to define new means, new norms – new ways of thinking. At times we’ve been considered revolutionary and even controversial, but like all pioneers, we bring the fight before the fight is won.
  • Sustainable At PIH we know good health –  good living – is a long term commitment. To be truly healthy, we must accept and devote ourselves to lifestyle changes, not quick fix pill-popping. And while these changes feel daunting at first, with PIH as a partner for life, daunting changes quickly give way to optimal health and vitality no pill can match. This is why our integrative solutions to health are designed with long term impact in mind so that we move beyond suppressing symptoms and instead, resolve the truer ailments that cause them.

Experience Perque's Activated Vitamin B12 Benefits - Order Today

best vitamin b12 for vegans
  • B-12 (hydroxocobalamin) - 2000 mcg.
  • Magnesium (C16, C18 alkyls) from whole untreated palm fruit  - 3.5 mg.
  • Phosphatidylethanolamine - 295 mg.
  • As a dietary supplement‚ take one (1) sublingual lozenge daily or as directed by your health professional. Place one lozenge under tongue and let dissolve.
  • Pregnant and nursing mothers need to check with their health professional before taking supplements.
  • Brand: Perque.
  • Form: Lozenges.
  • Quantity: 100.
  • Container: Glass bottle.
  • Storage: Keep in a cool dry place, keep out of reach of children.
  • Estimated shelf life from purchase: 1 - 2 years.

1. Glueck CJ, et al.: Evidence that homocys- teine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am J Cardiol 1995 Jan 15; 75: 132-136.
2. Andres E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blickle JF.VitaminB12 (cobalamin) deficiency in elderlypatients. CMAJ 2004 Aug 3;171(3):251-9.
3. Abalan F, Subra G. Picard M, Boueilh P. Incidence of vitamin B-12 and folic acid in patients admitted to a geriatric psychiatry unit. [Article in French] Encephale 1984; 10: 9-12.
4. Nilsson K, Gustafson L, Hultberg B: Plasma homocysteine is a sensitive marker for tissue deficiency of
both cobalamines and folates in a psychogeriatric population. Dement Geriatr Cogn Disord 1999 November- December; 10(6): 467-482.
5. Regland B, Andersson M, Abrahamson L, Bagby J, Dyrehag LE, Gottfries
6. CG: Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997; 26(4): 301-307.


The products and the claims made about specific products, articles and claims made in the articles and information written on or through this site have not been evaluated by Ancient Purity, the MHRA, the FSA or the United States FDA and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Providing a product for sale does not imply Ancient Purity recommendation of that product, its suitability or its efficacy. Ancient Purity cannot give medical opinions. No comment or entry in this site or in any communication from Ancient Purity may be taken as such.

Prices and promotions are subject to change without notice. Customers should always carefully check all the details printed on the package before opening the product. Whilst all efforts are made to ensure accuracy of description, specifications and pricing there may be occasions where errors arise. Should such a situation occur the company cannot accept your order. In the event of a mistake you will be contacted with a full explanation and a corrected offer. The information displayed is considered as an invitation to treat not as a confirmed offer for sale. The contract is confirmed upon supply of goods, Prices and promotions are subject to change without notice.

Please read the Terms and Conditions of using this site, by using the site you are accepting the terms and conditions.
All Material on this site © 2014 Ancient Purity Ltd Registered in England & Wales 07801142 VAT Reg 168 335 488