Folate Methylated 5-MTHF

Q: Why is Methyl Folate important?
A: Methyl Folate plays a crucial role in various biological processes, including DNA synthesis, red blood cell formation, neurotransmitter production, and homocysteine metabolism. It is particularly important during periods of rapid growth and development, such as pregnancy.

Q: Who should consider taking Methyl Folate supplements?
A: Methyl Folate supplements are commonly recommended for pregnant women, individuals with certain genetic polymorphisms (such as MTHFR mutations), people with folate deficiency, or those who may have a higher need for folate due to certain health conditions or medications.

Q: Can you give me a simple brief on Folate?
A: Sure, Folate and folic acid are nutrients required for many critical functions in the body. Unfortunately, many who have a genetic MTHFR mutation are unable to utilise these nutrients properly. L-Methylfolate(5-MTHF)has emerged as a popular alternative, and has been used as a complementary medicine in several recent clinical trials. Taking folate as MethylFolate can assist provide nutritional support for your body and brain. Our versatile supplement is also fundamental to the growth and renewal of our cells, aids regulate potentially harmful homocysteine, promotes healthy pregnancy, and much more.

Q: Can Methyl Folate interact with medications?
A: Methyl Folate may interact with certain medications, including some antiepileptic drugs, anti-depressants, and some cancer medications. It is important to inform your healthcare provider about all the medications you are taking to prevent any potential interactions.. 

Q: Is Methyl Folate the same as folic acid?
A: No, Methyl Folate is the active form of folate, while folic acid is the synthetic form commonly used in fortified foods and supplements. Some individuals have difficulty converting folic acid into Methyl Folate, so Methyl Folate supplements may be a better choice for them.

Q: Why is 5-MTHF critical for people with MTHFR mutations?
A: The MTHFR gene codes for the enzyme that activates folate. Mutations reduce its efficiency by up to 70%. Supplementing 5-MTHF skips the broken step and restores methylation, which supports detox, brain chemistry, fertility, and cardiovascular health.

Q: How does 5-MTHF affect mood and mental health?
A: It fuels production of neurotransmitters like serotonin, dopamine, and norepinephrine by supporting the cofactor BH4. Low methylfolate = low neurotransmitter synthesis, leading to depression, anxiety, and brain fog. Clinical trials show 5-MTHF works as a natural antidepressant adjunct.

Q: Can 5-MTHF really improve fertility in men and women?
A: Yes. In women, it supports egg maturation, endometrial lining health, and reduces miscarriage risk. In men, it improves sperm count, motility, and DNA stability. Folate is essential in passing on healthy genetic material to the next generation.

Q: How does 5-MTHF lower homocysteine and why does that matter?
A: 5-MTHF donates a methyl group to convert homocysteine into methionine, preventing its toxic build-up. High homocysteine damages blood vessels, drives clotting, and accelerates ageing. Healthy levels mean better heart health, clearer arteries, and sharper cognition.

Q: What’s the connection between 5-MTHF and detoxification?
A: Methylation (powered by 5-MTHF) activates detox enzymes, clears heavy metals, breaks down oestrogen, and helps the liver neutralise toxins. Without enough folate, detox stalls, leaving you with higher toxic load and hormone imbalances.

Q: How does 5-MTHF support anti-ageing and DNA repair?
A: It provides the raw materials for nucleotide synthesis, the building blocks of DNA. This means every time your cells replicate, they copy DNA more cleanly. That reduces mutations, stabilises telomeres, and keeps your cells “younger” for longer.

Q: Can 5-MTHF help with nerve and brain regeneration?
A: Yes. Alongside B12, folate is essential for methylation of myelin proteins that insulate nerves. Deficiency can cause neuropathy, tingling, memory decline, and cognitive drop. Restoring methylfolate supports myelin repair and brain resilience.

Q: How much 5-MTHF should someone take?
A: Typical supplemental doses range from 400mcg (basic support) to 5mg (therapeutic). The exact amount depends on genetics, homocysteine levels, and health goals. Many people start lower to avoid “methylation crashes” (anxiety, insomnia) and build up gradually.

Q: Should 5-MTHF be combined with other nutrients?
A: Yes. It works best with methylcobalamin (B12), riboflavin (B2), B6 (P5P), and betaine (TMG). These cofactors keep the methylation cycle balanced. Taking folate alone can sometimes cause imbalances, especially if B12 is low.

Q: Is there a risk of taking too much 5-MTHF?
A: High doses can overstimulate methylation, leading to irritability, anxiety, or sleep issues. This isn’t toxicity but imbalance. Balancing with niacin (which uses up excess methyl groups) or adjusting the dose usually resolves it.

Q: Why is folic acid in food and supplements still used if 5-MTHF is superior?
A: Folic acid is cheaper, stable, and has been mandated for fortification in many countries. But it is not natural to the body, and unmetabolised folic acid is linked to immune disruption and masking B12 deficiency. Biohackers and functional medicine practitioners almost always recommend 5-MTHF instead.

Q: How quickly can someone notice benefits from 5-MTHF?
A: For mood and energy, some feel improvements in days to weeks as neurotransmitter production increases. For fertility, detox, and DNA health, benefits accumulate over months of consistent use.

Q: What foods are rich in natural folate (not folic acid)?
A: Liver (especially beef and chicken liver), egg yolks, dark leafy greens, asparagus, and legumes. But cooking destroys a lot of folate, which is why supplementation is often needed for therapeutic effects.

• Take one capsule daily, with food or take it as directed by your healthcare practitioner. Do not exceed the recommended daily intake.

• Active 5-MTHF | L-Methylfolate - 400μg
• Alfalfa (Medicago Sativa) Powder

Other ingredients: Plant Material (Vegan) microcrystalline vegetable cellulose capsule.

• Brand: Ancient Purity.
• Form: Capsules.
• Quantity: 90.
• Container: Miron Glass bottle.
• Storage: Keep in a cool dry place, keep out of reach of children.
• Estimated shelf life from purchase: 1 - 2 years.