Folate Methylated 5-MTHF

Ancient Purity Active Folate 5-MTHF - For Methylation, Fertility and Cellular Longevity | Food State

• True Methylation and Detox Support - Provides bioactive 5-MTHF to drive methylation pathways that clear toxins, support DNA repair and protect cells from oxidative and mutational stress.
• No Synthetic Folic Acid - Uses L-Methylfolate rather than folic acid, avoiding unmetabolised folic acid accumulation which can interfere with detox and methylation pathways.
• Fertility, Pregnancy and Genetic Protection - Essential for neural tube development, endometrial health, egg quality and sperm DNA integrity. The form used by the body during conception and pregnancy.
• Food-Recognised and Highly Bioavailable - Absorbed in the small intestine and immediately usable at the cellular level. Stored in Miron Glass to protect potency and freshness.

Folate as 5-MTHF plays a central role in cellular life. It is required for DNA synthesis, repair and clean cell division, making it foundational for fertility, pregnancy, blood formation and long term tissue health. Adequate methylfolate reduces tiredness and fatigue, supports immune resilience and maintains healthy homocysteine metabolism, protecting blood vessels and cardiovascular integrity. Unlike folic acid, 5-MTHF enters metabolic pathways immediately without requiring enzymatic conversion.

This nutrient is critical for neurological and psychological function. Methylfolate directly supports the production of dopamine, serotonin and norepinephrine by feeding into BH4 dependent pathways. This makes it one of the most important nutrients for mood stability, motivation, cognitive clarity and stress resilience. By supporting mitochondrial efficiency and neurotransmitter synthesis, 5-MTHF helps maintain mental energy and emotional balance across all stages of life.

Modern toxic exposure places unprecedented strain on folate pathways. Glyphosate, heavy metals and environmental pollutants impair folate metabolism and increase the demand for active methylated nutrients. Synthetic folic acid can worsen this burden by competing for receptors and accumulating unmetabolised in the bloodstream. Ancient Purity Active Folate uses only 5-MTHF, the form required by those with MTHFR variants and anyone seeking optimal detox, fertility, longevity and epigenetic health.

Q: Why is Methyl Folate important?
A: Methyl Folate plays a crucial role in various biological processes, including DNA synthesis, red blood cell formation, neurotransmitter production, and homocysteine metabolism. It is particularly important during periods of rapid growth and development, such as pregnancy.

Q: Who should consider taking Methyl Folate supplements?
A: Methyl Folate supplements are commonly recommended for pregnant women, individuals with certain genetic polymorphisms (such as MTHFR mutations), people with folate deficiency, or those who may have a higher need for folate due to certain health conditions or medications.

Q: Can you give me a simple brief on Folate?
A: Sure, Folate and folic acid are nutrients required for many critical functions in the body. Unfortunately, many who have a genetic MTHFR mutation are unable to utilise these nutrients properly. L-Methylfolate(5-MTHF)has emerged as a popular alternative, and has been used as a complementary medicine in several recent clinical trials. Taking folate as MethylFolate can assist provide nutritional support for your body and brain. Our versatile supplement is also fundamental to the growth and renewal of our cells, aids regulate potentially harmful homocysteine, promotes healthy pregnancy, and much more.

Q: Can Methyl Folate interact with medications?
A: Methyl Folate may interact with certain medications, including some antiepileptic drugs, anti-depressants, and some cancer medications. It is important to inform your healthcare provider about all the medications you are taking to prevent any potential interactions.. 

Q: Is Methyl Folate the same as folic acid?
A: No, Methyl Folate is the active form of folate, while folic acid is the synthetic form commonly used in fortified foods and supplements. Some individuals have difficulty converting folic acid into Methyl Folate, so Methyl Folate supplements may be a better choice for them.

Q: Why is 5-MTHF critical for people with MTHFR mutations?
A: The MTHFR gene codes for the enzyme that activates folate. Mutations reduce its efficiency by up to 70%. Supplementing 5-MTHF skips the broken step and restores methylation, which supports detox, brain chemistry, fertility, and cardiovascular health.

Q: How does 5-MTHF affect mood and mental health?
A: It fuels production of neurotransmitters like serotonin, dopamine, and norepinephrine by supporting the cofactor BH4. Low methylfolate = low neurotransmitter synthesis, leading to depression, anxiety, and brain fog. Clinical trials show 5-MTHF works as a natural antidepressant adjunct.

Q: Can 5-MTHF really improve fertility in men and women?
A: Yes. In women, it supports egg maturation, endometrial lining health, and reduces miscarriage risk. In men, it improves sperm count, motility, and DNA stability. Folate is essential in passing on healthy genetic material to the next generation.

Q: How does 5-MTHF lower homocysteine and why does that matter?
A: 5-MTHF donates a methyl group to convert homocysteine into methionine, preventing its toxic build-up. High homocysteine damages blood vessels, drives clotting, and accelerates ageing. Healthy levels mean better heart health, clearer arteries, and sharper cognition.

Q: What’s the connection between 5-MTHF and detoxification?
A: Methylation (powered by 5-MTHF) activates detox enzymes, clears heavy metals, breaks down oestrogen, and helps the liver neutralise toxins. Without enough folate, detox stalls, leaving you with higher toxic load and hormone imbalances.

Q: How does 5-MTHF support anti-ageing and DNA repair?
A: It provides the raw materials for nucleotide synthesis, the building blocks of DNA. This means every time your cells replicate, they copy DNA more cleanly. That reduces mutations, stabilises telomeres, and keeps your cells “younger” for longer.

Q: Can 5-MTHF help with nerve and brain regeneration?
A: Yes. Alongside B12, folate is essential for methylation of myelin proteins that insulate nerves. Deficiency can cause neuropathy, tingling, memory decline, and cognitive drop. Restoring methylfolate supports myelin repair and brain resilience.

Q: How much 5-MTHF should someone take?
A: Typical supplemental doses range from 400mcg (basic support) to 5mg (therapeutic). The exact amount depends on genetics, homocysteine levels, and health goals. Many people start lower to avoid “methylation crashes” (anxiety, insomnia) and build up gradually.

Q: Should 5-MTHF be combined with other nutrients?
A: Yes. It works best with methylcobalamin (B12), riboflavin (B2), B6 (P5P), and betaine (TMG). These cofactors keep the methylation cycle balanced. Taking folate alone can sometimes cause imbalances, especially if B12 is low.

Q: Is there a risk of taking too much 5-MTHF?
A: High doses can overstimulate methylation, leading to irritability, anxiety, or sleep issues. This isn’t toxicity but imbalance. Balancing with niacin (which uses up excess methyl groups) or adjusting the dose usually resolves it.

Q: Why is folic acid in food and supplements still used if 5-MTHF is superior?
A: Folic acid is cheaper, stable, and has been mandated for fortification in many countries. But it is not natural to the body, and unmetabolised folic acid is linked to immune disruption and masking B12 deficiency. Biohackers and functional medicine practitioners almost always recommend 5-MTHF instead.

Q: How quickly can someone notice benefits from 5-MTHF?
A: For mood and energy, some feel improvements in days to weeks as neurotransmitter production increases. For fertility, detox, and DNA health, benefits accumulate over months of consistent use.

Q: What foods are rich in natural folate (not folic acid)?
A: Liver (especially beef and chicken liver), egg yolks, dark leafy greens, asparagus, and legumes. But cooking destroys a lot of folate, which is why supplementation is often needed for therapeutic effects.

• Take one capsule daily, with food or take it as directed by your healthcare practitioner. Do not exceed the recommended daily intake.

• Active 5-MTHF | L-Methylfolate - 400μg
• Alfalfa (Medicago Sativa) Powder

Other ingredients: Plant Material (Vegan) microcrystalline vegetable cellulose capsule.

• Brand: Ancient Purity.
• Form: Capsules.
• Quantity: 90.
• Container: Miron Glass bottle.
• Storage: Keep in a cool dry place, keep out of reach of children.
• Estimated shelf life from purchase: 1 - 2 years.