Boluoke® | Lumbrokinase

Boluoke® Lumbrokinase - Clinically Researched Enzyme for Healthy Blood Flow and Fibrin Balance

• Supports Healthy Blood State - Helps maintain balanced fibrin and fibrinogen levels, supporting smooth circulation and healthy blood viscosity.
• Clinically Studied Lumbrokinase - Extensively researched with clinical investigations involving multiple hospitals and large patient groups, making it the most studied lumbrokinase available.
• Targeted Enzyme Activity - Works through fibrinolysis support without interfering with the normal clotting cascade, unlike many other blood related enzymes.
• Pharmaceutical Grade Purity: Highly concentrated lumbrokinase without dilution from inactive earthworm proteins or bulk fillers found in inferior products.

Boluoke® contains lumbrokinase, a powerful enzyme originally identified in earthworms and used within Traditional Chinese Medicine for centuries. Modern research has focused on its ability to support fibrin balance and healthy blood flow, particularly in a world where sedentary lifestyles and chronic stress may contribute to thicker blood states. Unlike broader spectrum enzymes, lumbrokinase acts in a targeted manner aligned with the body’s natural fibrinolytic processes.

What distinguishes Boluoke® is its selective activity. It supports the reduction of excess fibrin and fibrinogen without altering standard coagulation markers, which is why it has been studied for compatibility alongside conventional medical therapies under professional supervision. This targeted approach differentiates it from enzymes such as nattokinase, which act more broadly within the clotting cascade.

Boluoke® is produced to pharmaceutical grade standards and has been evaluated in clinical research settings involving multiple hospitals and over a thousand participants. Many competing products labelled as lumbrokinase are heavily diluted with non active earthworm proteins and general proteolytic enzymes. Boluoke® is formulated to deliver true lumbrokinase potency, reflecting both traditional origins and modern scientific refinement.

Q: Can you explain how the product is extracted from the earthworm?
A: The lumbrokinase in Boluoke® comes from farmed earthworms that are raised in controlled environments. To obtain the enzyme, the worms are humanely sacrificed. The active ingredient is then carefully purified using modern laboratory techniques to ensure safety and consistency. Boluoke® is considered the gold standard of lumbrokinase supplements because of its strict quality controls and clinical support.

Q: Whats the difference between Boluoke® and other Lumbrokinase products?
A: Boluoke is the only Lumbrokinase product that has undergone all phases of clinical trials and standardised enzymatic strength against tPA and urokinase activities. Lumbrokinase extraction and purification methods determine the composition of the various enzyme fractions and enzymatic strength, making Boluoke® unique from other lumbrokinase products on the market.

Q: If i'm on blood thinning medication can i take Boluoke®? 
A: Lumbrokinase has been shown to safely coexist with blood thinning agents in various clinical studies. It does not have any adverse interactions and does not increase the likelihood of bleeding beyond what is inherent to blood thinners. However, patients should always consult with their physicians before taking Boluoke while on any prescriptions.

Q: If i'm having surgery is it safe to take Boluoke®?
A: Prior to undergoing surgery, it is recommended to stop taking Boluoke at least one week beforehand. After surgery, patients may resume taking Boluoke15 days later, or earlier if approved by a physician. While some high-risk patients may continue taking a small dosage of Boluoke® post-surgery, it is important to consult with a physician first.

Q: Can you explain how the product is extracted from the earthworm?
A: Boluoke® is produced using a highly purified enzyme complex derived from the earthwormLumbricus rubellus. The process involves carefully isolating the active protein fraction (lumbrokinase) through multiple steps of purification and filtration, ensuring that no whole worm parts, tissues, or environmental contaminants are present in the finished product.The extraction is carried out under strict Good Manufacturing Practice (GMP) standards. The final lumbrokinase enzyme complex is free from DNA and other non-protein components of the earthworm, making it a pure, standardised supplement.

Q: May I open the Boluoke® capsules and take it?
A: While preliminary coagulation tests indicate that Boluoke is still useful without the enteric coated capsules, patients are encouraged to take Boluoke® in its original capsulated format whenever possible.

Q: Is it safe to take Boluoke® and anti-platelet agents together?
A: Although there have been no studies looking at the interaction between Boluoke and anti-platelet agents, it is not recommended to use Boluoke with strong anti-platelets like Plavix or Ticlid unless under the supervision of a physician.

Q: is it safe to take Boluoke® and aspirin? 
A: Boluoke® has been shown to be safe when taken with aspirin in clinical studies, though patients should still discuss potential risks with their physician.

Q: I'm pregnant can I use Boluoke® ? 
A: While teratogenicity studies of Boluoke on animals showed no effect on pregnancy weight and fetal development, pregnant patients should not take Boluoke® unless it is approved and supervised by a physician.

Q: What are the contra-indications of Boluoke®?
A: Boluoke has several contra-indications, including allergy to lumbrokinase or earthworms, recent surgeries or punctures, high-risk aneurysms, internal bleeding or GI ulceration, bleeding disorders/tendencies, and taking anti-coagulants or anti-platelet drugs. Additionally, Boluoke® should not be used to replace Coumadin® unless patients refuse to take Coumadin® and the physician recommends it.

Q: Is Boluoke® really safe?
A: Clinically Researched & Standardised for Safety & Efficacy has shown...

• Boluoke is the only oral lumbrokinase on the market backed by decades of clinical trials in China (since 1992), with rigorous quality control.
• Enzymatic strength is guaranteed (minimum 12,000 Lumbrokinase Units per mg; ≥1.6 million tPA units per capsule).
• In a large Chinese clinical study (over 1,500 patients across 16 hospitals), adverse reactions were rare (~1.9%). Reported effects were mild—primarily itchiness, rash, or mild dig?_ symptoms; no major bleeding was observed.
• In Traditional Chinese Medicine, earthworms (Boluoke’s source) have been used for centuries to address circulatory issues, inflammation, and blood-related ailments.
• Modern applications use Boluoke specifically as an oral enzyme to promote circulatory health and manage coagulation balance.

Q: What side effects does Boluoke® have?
A: Boluoke has a low overall adverse reaction rate and is considered safe for most patients.

Q: Can you recommend a Boluoke® protocol?
A: It is recommended to take Boluoke® under a physician's guidance and protocol determined by the patient’s individual condition. See our Suggested use for as much information as we can give without a specific protocol.

Q: Are there tests to see what an appropriate dose of Boluoke® would be?
A: Tests such as anti-plasmin, prothrombin fragment 1+2, thrombin/antithrombin complex, or soluble fibrin monomer levels may be used to determine appropriate dosages.

Q: Does Boluoke® affect PT or aPTT?
A: Boluoke does not significantly alter PT or aPTT, unlike other lumbrokinase sources.

Q: Can I take Boluoke® with Vitamin K2?
A: Yes Boluoke (Lumbrokinase) is compatible with Vitamin K. 

• Take 1 capsule daily 30-45 minutes before meals.
• If using with chronic conditions take 1-3 times daily,
• For severe hypoperfusion, a practitioner may suggest taking two capsules three times daily for 3 to 6 weeks.
• Even if the Lumbrokinase is emptied from the capsule, it's advisable to take the powder on an empty stomach.
• Children: The manufacturer recommends a therapeutic dose of 1 capsule per 8Kg (about 17 pounds) per day.

Warning: Consult your physician before taking this product if you are on any prescription medicine, are pregnant, have bleeding risks or having surgery. If you have a known allergy to Lumbrokinase not take this product. Keep out of the reach of children.

• Proprietary Earthworm Protein Extract (Containing 300,000 LK units).

Other Ingredients: Acid resistant Hypromellose Capsules. Microcrystaline Cellulose. 

• Brand: Canada RNA Biochemical Inc.
• Size: 30 Capsules.
• Estimated shelf life from purchase: 2 years.
• Storage: Keep in a cool dry place. Keep out of reach of children.