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Vielight Pocket Miracle (Hair Re-Growth / Skin)

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Vielight Pocket Miracle (Hair Re-Growth / Skin)

The Pocket Miracle brings 4 applications of Low Level Laser Therapy to your fingertips. Made possible through 3 unique detachable adapters combined into 1 device. Cutting-edge ease in design makes Low Level Laser Therapy(LLLT) accessible to you from anywhere. Combines the utility of several LLLT devices into one through a breakthrough in engineering, without loss of power or utility.

Availability: In stock

£269.99

Details22

How does Low Level Laser Therapy work?  Cells contain cellular power plants called mitochondria. These mitochondria provide most of the required adenosine triphosphate(ATP) for cells. ATP is the chemical responsible for energy production within cells that fuel cellular and physiological functions including those directly related to injury repair and pain relief.
When a cell is damaged through injury or trauma, mitochondria lose their shape and their functional capability is lowered. This leads to a lower or complete stop of production for ATP and a lower rate of healing.

Research by Harvard University found that cells exposed to light radiation at the right frequency, re-energizes the mitochondria into producing increased amounts of ADP, which is later turned into ATP.

Laser therapy is the application of red light and near infrared radiation over injuries or lesions to stimulate healing and relieve pain without sensation or side effects. It is popularly used for the treatment of sports injuries, several different chronic pain syndromes and non-healing wounds such as venous and diabetic ulcers. Many new applications for this treatment are being used and investigated including smoking cessation, weight loss, addiction therapy, nerve regeneration for spinal cord injuries, and muscle atrophy for astronauts on long term space missions. The term adopted by NASA and U.S. military scientists is Photobiomodulation. Effectiveness of Laser Therapy depends on the color of the light (wavelength), intensity, and total energy delivered.

Photobiomodulation (Photobiology)
In visible radiation, when a photon is absorbed by a molecule, the electrons of the molecule are raised to a higher state. This molecule will then lose the extra energy in one of two ways –

  • Emitting a photon of longer wavelength(less energy)
  • Undergoing photochemistry

The first law of photobiology states that in order for a reaction to occur, absorption must take place first. This law is important in regards to understanding how safety functions for a laser. As an example, blue light is ‘safe’ for pure DNA since DNA  absorbs UV light(100-400 nm). [1] However, bilirubin absorbs blue light and undergoes a photochemical change when absorbed.

An absorption spectrum (A) is a plot of the probability that light of a certain wavelength will be absorbed by the intended system. Running one in regards to the chemical or biological system under investigation will determine its light absorbing properties.

The quantum yield (Φ) is the probability that a photochemical reaction will occur when light energy is absorbed into the system.

The true photochemical sensitivity of a system is equivalent to the absorption spectrum multiplied by the quantum yield : (A) · (Φ)

In an ideal scenario, a plot of the efficacy of different wavelengths of light(action spectrum) on a system should mimic the absorption spectrum (A) of the molecule that is absorbing the light. Thus, by running an action spectrum, one can identify the molecule whose photochemical alteration results in the effect.

Example

Action spectrum

Figure 1 : Action spectrum of the plot of the reciprocals of incident energy for 50% killing of Escherichia coli versus light wavelength. In Figure 1, an observable action spectrum in regards to the killing of bacteria(E. coli) mimics the absorption spectrum of DNA. This correlates with current knowledge on how DNA is vital to a cell.

Biostimulation
A chain of molecular events has been proposed to explain the effects of photobiomodulation. Starting with the absorption of light, this leads to signal transduction and amplification, which finally results in the photoresponse.

Photobiomodulation

Figure 2 : A model for the mechanism of photobiomodulation. This picture illustrates the sequence of events that occur when the electrons of a cell are energized and raised to a higher state, depending on the wavelength received.

How does Low Level Laser Therapy work for the regrowth of hair? 

  • Low Level Laser Therapy irradiates the scalp, stimulating the growth factors that support hair growth and improve blood circulation. This helps to stop and reverse hair thinning.
  • Low Level Laser Therapy may influence hair regrowth via the nerve growth factor(NGF) and the neurotrophin receptor p75(NTRp75) signalling system.[1][2] It has been found that NGF promotes growth through the transforming tyrokinase protein(TrkA). NGF and the NTRp75 are important hair growth terminators.[3]

WrKExNo

Figurative illustration of LLLT on hair follicles.

How does Low Level Laser Therapy help with skin rejuvenation?
Low Level Laser Therapy has been shown to be effective for improving wrinkles and skin laxity. Skin starts showing its first signs of aging in the late 20s to early 30s – wrinkles, dyspigmentation, telangiectasia, and loss of elasticity.
Common histologic and molecular-level features are reduction in the amount of collagen, fragmentation of collagen fibers, elastotic degeneration of elastic fibers, upregulation of matrix metalloproteinases(MMP), dilated and tortuous dermal vessels, and atrophy and disorientation of the epidermis.[2]
Low Level Laser Therapy has been scientifically proven to increase the production of procollagen, collagen, and basic fibroblast growth factors (bFGF), as well as proliferation of fibroblasts after exposure to low-energy laser irradiation in in vitro and in vivo animal models.[10,11]

 

skin rejuvenation

Figure 1 : Possible mechanism of actions for LLLT’s effects on skin rejuvenation

LLLT is known to increase microcirculation and vascular perfusion in the skin, alter platelet-derived growth factor (PDGF) and transforming growth factor (TGF-1) expressions, and inhibit apoptosis.[12,13] Positive histologic and ultrastructural changes were observed after a combination of 830-nm, and 633-nm LED phototherapy and observed alteration in the status of MMPs and tissue inhibiting matrix metalloproteinases(TIMPs).[18]

Furthermore, mRNA levels of interleukin(IL)-1, tumor necrosis factor(TNF-), intercellular adhesion molecule(ICAM-1), and connexin were increased after LED phototherapy, whereas interleukin(IL)-6 levels were decreased.[18] Proinflammatory cytokines(IL-1/TNF) are thought to be recruited to heal the intentionally formed photothermally mediated wounds associated with laser treatments, and this cascade of wound healing consequently contributes to new collagen synthesis.[18]

When these observations are put together, it is possible that increased production of IL-1 and  TNF- might have induced MMPs in the early response to
LED therapy. This may clear the photodamaged collagen fragments to enable biosynthesis of new collagen fibers.[18]
Later, an increase in the amount of TIMPs might protect the newly synthesized collagen from proteolytic degradation by MMPs. Furthermore, increased expression of connexin may possibly enhance cell-to-cell communication between dermal components, especially the fibroblasts, and enhance the cellular responses to the photobiostimulation effects from LED treatment, to produce new collagen in a larger area that even includes the nonirradiated regions.[18]

Clinical studies
In a clinical study performed by Weiss et al, 300 patients received LED therapy (590 nm, 0.10 J/cm2) alone, and 600 patients received LED therapy in combination with a thermal-based photorejuvenation procedure. Among patients who received LED photorejuvenation alone, 90% reported that they observed a softening of skin texture and a reduction in roughness and fine lines, ranging from a significant reduction to sometimes subtle changes.[5]
Moreover, patients receiving a thermal photorejuvenation laser with or without additional LED photomodulation reported a prominent reduction in posttreatment erythema and an overall impression of increased efficacy with the additional LED treatment. This reduction in posttreatment erythema could be attributed to anti-inflammatory effects of LLLT.[9]

Using different pulse sequence parameters, a multicenter clinical trial was conducted, with 90 patients receiving 8 LED treatments over 4 weeks.[6,15-17] The outcome of this study showed very favorable results, with 90% of patients improving by at least one Fitzpatrick photoaging category and 65% of patients demonstrating global improvement in facial texture, fine lines, background erythema, and pigmentation. The results peaked at 4-6 months after completion of 8 treatments. Markedly in-creased collagen in the papillary dermis and reduced MMP-1 were common findings.[9]
Barolet et al’s study is also consistent with the previously mentioned studies. They used a 3D model of tissue-engineered human reconstructed skin to investigate the potential of 660-nm, 50-mW/cm, 4-J/cm2 LED in modulating collagen and MMP-1, and results showed upregulation of collagen and downregulation MMP-1 in vitro.[9]

A split-face single-blinded clinical study was then carried out to assess the results of this light treatment on skin texture and appearance of individuals with aged/photoaged skin. After 12 LED treatments, profilometry quantification demonstrated that 90% of individuals had a reduction in rhytid depth and surface roughness, and 87% reported that they have experienced a reduction in the Fitzpatrick wrinkling severity score.[9]

How does Low Level Laser Therapy alleviate pain?
There are two known mechanisms : Anti-inflammatory - LLLT reduces oxidative stress : Irradiance of suitable wavelength that is applied to injuries will be absorbed by cytochrome c oxidase – displacing nitric oxide thereby reducing inflammation and increasing ATP production.
Analgesia - LLLT creates a nerve block. : High irradiance energy treatments can induce an analgesic effect by disrupting pain signals.

Psychogenic Pain Relief
Migraines do not involve any pain receptor nerves. Migraines are the result of a neurovascular disorder. The trigemino-cerebrovascular system is involved with the formation of migraines. The trigemino-cerebrovascular system is a pain control system found in the brain which supplies the outermost layer of the brain with sensory nerve fibers. Low level laser therapy creates a state of vasodilation by activating the nitric oxide pathway which increases blood flow and oxygen delivery to the brain, helping to mitigate the symptoms of a migraine.

 

laser penetration - Copy

 Figure 1 : Tissue penetration depths of various wavelengths.

How does Low Level Laser Therapy accelerate wound healing?
Low Level Laser Therapy has been found to accelerate wound healing in traumatic or post-surgical wounds. Furthermore, it helps against hypertrophic scarring and keloid formation. [1]

The major cells of importance in wound healing are :

3 stages of wound healing: Proliferation, Inflammation, Remodeling.
Three decades worth of study : Research has shown that the mechanisms involved are wavelength dependent and occur at a cellular and subcellular levels. Two wavelengths stand out the most from data collected over 30 years – 830 nm and 633 nm.

Table1

Near-IR at 830 nm is particularly associated with the proliferation of fibroblast cells, inflammatory scavenger cells, macrophages, leukocytes and mast cells. Visible red light at 633 nm is particularly associated with the reparative cells, fibroblasts and endotheliocytes.
Both wavelengths have been shown to activate the epidermal mother keratinocytes to synthesize useful cytokines which enter the dermis and assist with the cellular processes and maintaining matrix homeostasis.[2]

Clinical trials
Some of the mechanisms behind the efficacy of low level light therapy at appropriate wavelengths have already been partly elucidated, such as the wavelength specific activation of the dermal and epidermal cells associated with the three phases of the wound healing.[3-7]
Karu has suggested that the latency effect of phototherapy in cells actually continues in subsequent generations of the irradadiated cells in a chapter of her latest book. This is an important implication in Low Level Laser Therapy, given that cells are continuously renewed during the process of wound healing.

Blood flow and wound healing
In an experiment, the increase in local blood flow around the local wound area from irradation by an 830 nm laser, increased the positive likelihood of flap survival on mice.[8] There was significantly better survival correlated with increased perfusion in the 830 nm Low Level Laser Therapy-treated flaps – assessed with laser Doppler speckle flowmetry. An increase in blood flow increases the flow of oxygen and nutrients towards the local wound area. An increase in blood flow establishes a higher oxygen tension in the local wound area, which forms multiple gradients between the damaged area and the surrounding tissue, connecting the reparation cells.[9, 10]

Wound healing references

  1. Bolton, Y. S., Dyson, M., Harvey, W., & Diamantopoulos, C. (1989). Macrophage responsiveness to light therapy,. Lasers Surg Med , 497-505.
  2. Calderhead, R., Kubota, J., Trelles, M., & Ohshiro, T. (2008). One mechanism behind LED phototherapy for wound healing and skin rejuvenation: key role of the mast cell. Laser Therapy, 17, 141-148.
  3. Karu, T. (2007). Ten Lectures on Basic Science of Laser Phototherapy. Prima Books AB .
  4. Kubota, J. (2004). Defocused diode laser therapy (830 nm) in the treatment of unresponsive skin ulcers: a preliminary trial. J Cosmet Laser Therapy, 6 , 96-102.
  5. Kubota, J. (2004). Effects of diode laser therapy on blood flow in axial patter flaps in the rat model. Lasers Med Sci, 17 , 146-153.
  6. McLoda, T. A., Hopkins, J. T., Seegmiller, J. G., & Baxter, G. D. (2004). Low-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study. J Athl Train(PubMed) , 223-229.
  7. Osanai, T., Shiroto, C., Mikami, Y., & Kudou, E. (1990). Measurement of GaAIAs diode laser action on phagocytic activity of human neutrophils as a possible therapeutic dosimtery determinant. Laser Therapy , 123-124.
  8. Trelles, M. (2006). Phototherapy in anti-aging and its photobiological basics: a new approach to skin rejuvenation. J Cosmet Dermatol, 5 , 87-91.
  9. Trelles, M., Rigau, J., & Velez, M. (2002). LLLT in vivo effects on mast cells. Simunovic Z (Ed) Lasers in Medicine and Dentistry(Part 1), Laser Medico, Switzerland , 169-186.
  10. Zhevago, N., & KA, S. (2006). Proand anti-inflammatory cytokine content in human peripheral blood after its transcutaneous(in vovo) and direct(in vitro) irradiation with polychromatic visible and infrared light. Photomed Laser Surgery , 123-139.

Hair Re-growth references:

  1. E.M. Peters, S. Hendrix, G. Golz, B.F. Klapp, P.C. Arck and R. Paus, Nerve Growth Factor and Its Precursor Differentially Regulate Hair Cycle Progression in Mice, J Histochem Cytochem (2005).
  2. V.A. Botchkarev, N.V. Botchkareva, K.M. Albers, L.H. Chen, P. Welker and R. Paus, A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression, Faseb J 14 (2000) 1931-42.
  3. F. Schwartz, C. Brodie, E. Appel, G. Kazimirsky and A.Shainberg, Effect of helium/neon laser irradiation on nerve growth factor synthesis and secretion in skeletal muscle cultures, J Photochem Photobiol B 66 (2002) 195-200.

Skin rejuvination References

  1. Kligman LH. Photoaging. Manifestations, prevention, and treatment. Clin Geriatr Med. 1989;5:235-251.
  2. Takema Y, Yorimoto Y, Kawai M, et al. Age-related changes in the elastic properties and thickness of human facial skin. Br J Dermatol. 1994;131:641-648.
  3. Dierickx CC, Anderson RR. Visible light treatment of photoaging. Dermatol Ther. 2005;18:191-208.
  4. Weiss RA, Weiss MA, Geronemus RG, et al. A novel non-thermal non-ablative full panel LED photomodulation device for reversal of photoaging: Digital microscopic and clinical results in various skin types. J Drugs Dermatol. 2004;3:605-610.
  5. Weiss RA, McDaniel DH, Geronemus RG, et al. Clinical experience with light-emitting diode (LED) photomodulation. Dermatol Surg. 2005;31:1199-1205.
  6. Weiss RA, McDaniel DH, Geronemus RG, et al. Clinical trial of a novel non-thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results. Lasers Surg Med. 2005;36:85-91.
  7. Bhat J, Birch J, Whitehurst C, et al. A single-blinded randomised controlled study to determine the efficacy of Omnilux revive facial treatment in skin rejuvenation. Lasers Med Sci. 2005;20:6-10.
  8. Russell BA, Kellett N, Reilly LR. A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation. J Cosmet Laser Ther. 2005;7:196-200.
  9. Barolet D, Roberge CJ, Auger FA, et al. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: Clinical correlation with a single-blinded study. J Invest Dermatol. 2009;129:2751-2759.
  10. 10. Abergel RP, Lyons RF, Castel JC, et al. Biostimulation of wound healing by lasers: Experimental approaches in animal models and in fibroblast cultures. J Dermatol Surg Oncol. 1987;13:127-133.
  11. Yu W, Naim JO, Lanzafame RJ. The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts. Photochem Photobiol. 1994;59:167-170.
  12. Schindl A, Heinze G, Schindl M, et al. Systemic effects of low-intensity laser irradiation on skin microcirculation in patients with diabetic microangiopathy. Microvasc Res. 2002;64:240-246.
  13. Ben-Dov N, Shefer G, Irintchev A, et al. Low-energy laser irradiation affects satellite cell proliferation and differentiation in vitro. Biochim Biophys Acta. 1999;1448:372-380.
  14. Kucuk BB, oral K, Selcuk NA, et al. The anti-inflammatory effect of low-level laser therapy on experimentally induced inflammation of rabbit temporomandibular joint retrodiscal tissues. J Orofac Pain. 2010;24:293-297.
  15. Geronemus RG, Weiss RA, Weiss MA, et al. Non-ablative LED photomodulation light activated fibroblast stimulation clinical trial. Lasers Surg Med. 2003;25:22.
  16. McDaniel DH, Newman J, Geronemus R, et al. Non-ablative nonthermal LED photomodulation—A multicenter clinical photoaging trial. Lasers Surg Med. 2003;15:22.
  17. Weiss RA, McDaniel DH, Geronemus R, et al. Non-ablative, nonthermal light emitting diode (LED) phototherapy of photoaged skin. Lasers Surg Med. 2004;16:31.
  18. Lee SY, Park KH, Choi JW, et al. A prospective, randomized, placebocontrolled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol B Biol.2007;88:51-67.

Pain relief references

  • Bao, P., Kodra, A., Tomic-Canic, M., S. Golinko, M., Ehrlich, P., & Brem, H. (2008). The Role of Vascular Endothelial Growth Factor in Wound Healing. PubMed .
  • Calderhead, R. G. (2013). Photobiological Basics of Photosurgery and Phototherapy. South Korea: Hanmi Medical Publishing Co.
  • Chow, R. T., Johnson, M., Lopes-Martin, R., & Bjordal, J. (2009). Efficacy Of Low-Level Laser Therapy In The Treatment Of Neck Pain.http://www.medicalnewstoday.com/articles/170796.php.
  • Hagiwara, S., Iwasaka, H., Okuda, K., & Noguchi, T. (2007). GaAlAs (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. PubMed .
  • Hamblin, M., & Demidova, T. (2006). Mechanisms of Low Level Light Therapy.
  • Hinz, B. (2007). Formation and function of the myofibroblast during tissue repair. PubMed .
  • Hopkins, J., McLoda, T., Seegmiller, J., & Baxter, D. (2004). Low-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study. PubMed .
  • Hospital, S. J. (2007, June 3). Science Daily. Retrieved Jan 7, 2014, from Science Daily: http://www.sciencedaily.com/releases/2007/06/070601152207.htm
  • Karu, T., Kalendo, G. S., Letokhov, V. S., & Lobko, V. V. (1982). Biostimulation of HeLa cells by low-intensity visible light.
  • Khanna, A., Shankar, L., Keelan, M., Kornowski, R., Leon, M., Moses, J., et al. (1999). Augmentation of the expression of proangiogenic genes in cardiomyocytes with low dose laser irradiation. PubMed .
  • Kipshidze, N., Nikolaychik, V., Keelan, M., Shankar, L., Khanna, A., Kornowski, R., et al. (2001). Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro. PubMed .
  • L, G., Asher, Y., Becker, Y., & Kleinman, Y. (2004). Low level laser irradiation stimulates mitochondrial membrane potential and disperses subnuclear promyelocytic leukemia protein.PubMed, Wiley-Liss.
  • Link, A. S., Kuris, A., & Edvinsson, L. (2007). Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system. PubMed .
  • Maassenvandenbrink, A., & Chan, K. (2008). Neurovascular pharmacology of migraine. PubMed .
  • Medrado, A., Pugliese, L., Reise, S., & Andrade, Z. (2003). Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts. PubMed .
  • Nordqvist, C. (2009, April 9). What Is Pain? What Causes Pain? Retrieved January 1, 2014, from www.medicalnewstoday.com: http://www.medicalnewstoday.com/articles/145750.php
  • Poon, V., Huang, L., & Burd, A. (2005). Biostimulation of dermal fibroblast by sublethal Q-switched Nd:YAG 532 nm laser: collagen remodeling and pigmentation.
  • Schoenhoff, F., Griswold, B., Matt, P., Sloper, L., Yamazaki, M., Carlson, O., et al. (2009). Abstract 5095: The Role of Circulating Transforming Growth Factor-β in Vascular Ehlers-Danlos Syndrome: Implications for Drug Therapy.
  • Smith, K. C. (1991). The Photobiological Basis of Low Level Laser Therapy. 19-24.
  • Stephan, W., J. Banas, L., Bennett, M., & Huseyin, T. (2012). Efficacy of super-pulsed 905 nm Low Level Laser Therapy in the Management of Traumatic Brain Injury.
  • Yu, H., Chang, K., Yu, C., Chen, J., & Chen, G. (1996). Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes. PubMed .

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  • Vielight Pocket Miracle User Guide | Link.

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  • Brand: Vielight.
  • Warranty: One-year manufacturer’s warranty.

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