WORLDWIDE
Shipping Available

ORDER / TALK TO US
03330 112 829
10AM - 5:30PM UK

Accepted Payments
cart
item - £0.00

You have no items in your shopping cart.

Subtotal
£0.00

Alpha-Lipoic Acid (Detox/Antioxidant/Eye/) 60 caps

More Views

Alpha-Lipoic Acid (Detox/Antioxidant/Eye/) 60 caps

Be the first to review this product

Alpha Lipoic Acid (ALA) broad-spectrum protection against such ailments as painful neuropathy, migraine headaches, disabling cataracts and neurodegenerative conditions. Optimise your body’s levels of protective antioxidants with ALA, a sulphur-containing molecule that is synthesised in your body from the fatty acid octanoic acid.

Availability: In stock

£19.99

Details22

Alpha-Lipoic Acid is an essential co-factor in energy metabolism in organisms from microbes to humans, ALA is a potent antioxidant that is capable of scavenging harmful free radicals from your tissues. Simply defined it is a substance (such as a co-enzyme) that must be available in order for another substance (such as an enzyme) to produce a specific result. Additionally, when present in sufficient quantities, Alpha Lipoic Acid acts as an antioxidant. The amount of Alpha Lipoic Acid naturally present in the body may not be adequate to obtain the antioxidant benefits. Increasing the amount of Alpha Lipoic Acid through dietary supplementation can be helpful to perform this vital function. Dr Elson Haas, the author of “Staying Healthy with Nutrition,” states that ALA’s unique structure allows it to perform effectively as an antioxidant in both aqueous and fat-based environments, making ALA valuable both inside and outside your cells.

The combination of these two attributes makes Alpha Lipoic Acid a unique antioxidant supplement. Your body does, in fact, manufacture Alpha-Lipoic Acid, but supplementing it provides benefits beyond its involvement in carbohydrate metabolism. For starters, Alpha-Lipoic Acid is able to deactivate both fat and water-soluble free radicals (build-up of excess minerals underneath the surface of your skin) and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. To give a more understandable answer, for those who just want to know what Alpha-Lipoic Acid can do for them, it helps to take the toxins out of the body thereby improving overall health.

Alpha Lipoic Acid offers the following essential health benefits:

  • Reduces oxidative stress in the body via powerful antioxidant activity 1,3-5
  • Potent heavy metal chelator 22,23
  • Improves several components of the metabolic syndrome 6.
  • Recycles coenzyme Q10 and NAD (nicotinamide adenine dinucleotide).  
  • Reduces blood pressure 
  • Reduces insulin resistance 
  • Improves the lipid profile 
  • Increases insulin sensitivity 8
  • Improves diabetic neuropathy 9,10
  • Protects against cataract formation 11
  • Improves visual function in glaucoma 12
  • Helps prevent retinal cell death when combined with vitamin E in retinitis pigments 13
  • Reduces brain damage after a stroke 15
  • Prevents bone loss, possibly through an anti-inflammatory effect 19-21
  • Reduces frequency and intensity of migraines 24
  • Improves skin texture 25
  • Of the free radical scavengers, it's the only one known to easily get into your brain.

The benefits of ALA can appear near miraculous. For example, according to Dr Berkson, Russia has successfully used ALA intravenously to reverse ischemia reperfusion injuries by injecting it right after a heart attack or a stroke. 

There’s even been quite a bit of research showing it can restore T cell function. T cells are a type of white blood cells that are of key importance to your immune system and are at the core of adaptive immunity, the system that tailors your body's immune response to specific pathogens.

Antioxidants
Your entire body, including your DNA, is under endless, daily assault from a variety of sources, from poor diets to pollution. Think of your cells, including your brain cells, each getting hit by free-radicals thousands of times a day. This violent process is called "oxidation,” which damages your cells.

Antioxidants are the answer...... They include vitamins and other nutrients that target free radicals. 
Food, particularly fruits and vegetables, is a powerful source of these valiant protectors, and your body produces some itself. Their role is to limit the damage to your cells, which can slow down disease and signs of ageing. 
In the case of alpha lipoic acid, your body does produce it in minute quantities, but most of it comes from your diet. However, if you are a vegan/vegetarian you may struggle as its main sources are from grass-fed red meat and organ meats.

It also has the ability to regenerate other antioxidants such as vitamins C, E, and glutathione. So, when your body has used up these antioxidants, if there’s ALA around, it helps regenerate them. 
You may not know this, but glutathione is another very important antioxidant. You can get it from supplements, but the only form that works effectively is the reduced form, which is difficult to absorb when taken orally. It is much more cost effective to supplement with precursors or items like alpha lipoic acid that regenerates glutathione. 

Neuroprotection
Given its strong ability to neutralize the damaging effects of oxidative stress, lipoic acid is the subject of intense study in preventing free radical damage to the neurological system. 14
Lipoic acid is able to pass readily into the brain and reach all parts of a nerve cell. Experimental studies have shown that lipoic acid reduced brain damage after a stroke and that those animals who received lipoic acid had a survival rate three times greater than those that did not.15 Some of the protective effects conferred by lipoic acid in promoting healthy nerve function may be related to its ability to regenerate the antioxidant glutathione, which is often significantly depleted by harmful oxidative stress associated with cerebrovascular events such as stroke. 

New evidence also suggests that lipoic acid may help guard against one of the most dreaded conditions associated with aging—Alzheimer’s disease. Researchers have identified a series of mechanisms through which lipoic acid may work in helping prevent or manage Alzheimer’s disease.16 Scientists believe that lipoic acid may increase the production of acetylcholine, an essential nervous system messenger that is deficient in the brains of Alzheimer’s disease victims. 

In addition, preliminary works suggest that lipoic acid might be useful in those affected by multiple sclerosis. Investigators found that lipoic acid supplementation improved a variety of inflammatory measures that are associated with the disease.17 Further evidence also showed that lipoic acid supplementation produced improvements in animals suffering from an experimentally induced form of multiple sclerosis. 18

Promoting Better Eye Health
Lipoic acid offers promise in supporting optimal visual health. 
As adults grow older, they become more vulnerable to developing cataracts, opacities of the lens that cloud sight. A key problem involved in cataract formation is oxidative stress in the lens of the eye. Lipoic acid was found to offer notable protection against cataract formation in an experimental animal model. Scientists believe that lipoic acid may confer this benefit by increasing levels of essential endogenous antioxidant enzymes such as glutathione peroxidase.11

Another common cause of vision loss is glaucoma. A study in patients with open-angle glaucoma found that visual function and other measures of glaucoma were improved in a group that received either 75 mg of lipoic acid daily for two months or 150 mg of lipoic acid daily for one month, compared with a control group that received no lipoic acid.12

Furthermore, a recent study revealed that the combination of lipoic acid and vitamin E helped prevent retinal cell death in animals with retinitis pigmentosa, an eye disease that also affects humans. As there is currently no effective medical treatment for this vision-robbing disease, the discovery of a nutritional approach to potentially treat retinitis pigmentosa is amazing news indeed. 13

Preserving Bone Density
Another area in which lipoic acid holds promise is in averting the bone loss that accompanies osteoporosis and other degenerative bone conditions. This multifaceted agent may help preserve bone health by quelling the oxidative stress that threatens to degrade healthy bone density.
When applied to bone marrow cells and osteoblasts (bone-forming cells) in the laboratory, lipoic acid suppressed the formation of bone-degrading osteoclast cells in a dose-dependent fashion.19,20 It also reduced the process of inflammation-induced bone loss in both laboratory and living systems.19 Scientists believe that lipoic acid’s ability in preventing the loss of bone is linked to its inhibitory effects on pro-inflammatory prostaglandin E2 and the inflammatory cytokine tumour necrosis factor-alpha. 20,21
These promising preliminary findings suggest a therapeutic role for lipoic acid in preventing and managing osteoporosis and other conditions that threaten bone density.

Metal Chelation
Lipoic acid may also protect the body against toxic metal contaminants found in the environment and food supply. This multifunctional agent works by chelating these dangerous agents, such as arsenic, cadmium, lead, and mercury and rendering them inactive so that they can be removed by the body. In animal studies, lipoic acid has been shown to provide protection against arsenic poisoning and to safeguard the liver against the effects of cadmium exposure.5,22 Another study also showed that lipoic acid helped protect the delicate nervous system against the harmful effects of mercury poisoning.23

Migraine Prevention
Preliminary evidence suggests that lipoic acid could offer welcome relief for migraine sufferers. When a group of these individuals received a supplement of 600 mg of lipoic acid each day for three months, the frequency and intensity of their migraines declined modestly, and they also reported suffering fewer headache days. 24

Metabolic Syndrome and Diabetes
Overwhelming evidence now suggests that lipoic acid may be critical for not only maintaining optimal blood sugar levels by helping the body to use glucose but also for supporting insulin sensitivity and key aspects of cardiovascular health, such as endothelial function.

According to a just-released review of experimental studies, lipoic acid can help relieve several components of metabolic syndrome—a constellation of risk factors that often precedes full-blown types 2 diabetes. This review revealed that lipoic acid reduces blood pressure and insulin resistance, improves the lipid profile, and reduces weight. Scientists are encouraged by lipoic acid’s potential as a therapeutic agent for individuals with metabolic syndrome.6

Furthermore, another recent study of 36 patients with coronary artery disease found that a combination of lipoic acid with acetyl-L-carnitine reduced blood pressure and improved endothelial function of the brachial artery.7 This nutrient pair may, therefore, be an effective strategy for supporting healthy blood pressure levels, particularly in the context of metabolic syndrome.
Just last year, investigators revealed dramatic effects of administering lipoic acid in improving insulin sensitivity in overweight adults suffering from type 2 diabetes. Lipoic acid produced significant improvements in a very short time frame—only four weeks of supplementation.8 This finding could have important implications, as insulin resistance lies at the heart of type 2 diabetes.

Even after complications of diabetes have manifested, lipoic acid offers help. It has been found effective in the treatment of diabetic neuropathy, a type of nerve damage that occurs as a result of the toxic effects of high glucose levels on the nervous system in diabetes. Diabetic neuropathy is characterized by numbness, tingling, and pain best described as “burning” in the extremities.9
A large, randomized, placebo-controlled, multicenter, double-blind study involving 328 patients with type 2 diabetes revealed that lipoic acid significantly improved symptoms of diabetic neuropathy, including sensations of burning, tingling, itching, and pain.9 Although this early study was carried out using intravenous infusions of lipoic acid, later research has shown oral lipoic acid supplements to also be effective. Just five weeks of oral supplementation with lipoic acid significantly improved the stabbing pain, burning pain, and numbness of the feet in patients suffering from diabetic neuropathy, with the dose-effectiveness range being 600-1,800 mg of lipoic acid dosed orally per day.10 The dose of R-lipoic acid to achieve this effect in diabetics would be half this amount since it is the “R” form of lipoic acid that is biologically active in the body.

Maintaining Healthy Skin
Among the myriad benefits of lipoic acid, scientists have found that it can also be used to improve the health of the skin. A study of 33 women with an average age of 54 years found that twice-daily application of a cream containing 5% lipoic acid for three months reduced the roughness of the skin and decreased the appearance of photoaging, compared with a control cream. 25

Dr Burt Berkson Studies
Dr Burt Berkson was given several patients who were expected to die from hepatitis C. His job was more or less to simply babysit them in the ICU and watch them die. But Dr Berkson was a rebel at heart and he simply couldn’t do that. Instead, he called an associate at the National Institutes of Health and found out how he could treat them. He learned that alpha lipoic acid had some impressive experimental support. Remarkably, although these patients were expected to die within a few weeks, they all completely recovered!

However not all went well for Dr Berkson as he made his superiors look foolish and they simply could not tolerate that so rather than embrace his findings, they actively suppressed the results and made his life miserable for showing them up.

This was a pivotal moment in Dr Berskson’s career and caused him to make choices that eventually led to where he is at now. Since then, Dr Berkson has lectured all over the world on this topic and published a study on the use of antioxidants for health over hepatitis C.  His first book, The Alpha-Lipoic Acid Breakthrough was published in 1998.
Clinically, alpha lipoic acid seems to be a useful supplement in treating hepatitis C. It can also be used for painful nerve conditions in diabetes and may help slow down the ageing process itself through its reduction in free radicals.

Dr Berkson uses ALA along with low dose naltrexone (LDN) for health over serious health issues such as Lupus  / Rheumatoid arthritis / Dermatomyositis (an inflammatory muscle disease) / Autoimmune diseases. Most of his patients normalize in about one month on this combination of ALA and LDN.

What is Low Dose Naltrexone?
Naltrexone (generic name) is a pharmacologically active opioid antagonist, conventionally used to treat drug- and alcohol addiction – normally at doses of 50mg to 300mg. As such, it’s been an FDA approved drug for over two decades. 
However, researchers have found that at very low dosages (3 to 4.5 mg), naltrexone has immunomodulating properties that may be able to successfully treat some major health issues.
As explained on the informative website www.lowdosenaltrexone.org, when you take LDN at bedtime -- which blocks your opioid receptors for a few hours in the middle of the night -- it is believed to up-regulate vital elements of your immune system by increasing your body’s production of metenkephalin and endorphins (your natural opioids), hence improving immune function.

Using when Working out
Alpha lipoic acid can be a potent aid when you exercise vigorously. Dr Berkson gives an anecdotal story about a friend – an international weightlifting champion – who regularly uses ALA prior to meets. Unfortunately, there are no set guidelines on dosage and timing. It can be highly individual and is something that requires a little bit of trial and error in order to get it just right. But if you suffer from any of the conditions listed above or diabetes it would certainly seem like a useful supplement to consider.

Using Lipoic Acid
The amount of lipoic acid produced internally in the body decreases naturally with age, which could set the stage for free radical-induced damage. Although small amounts of lipoic acid are available in food sources, such as dark leafy greens like spinach and collards, broccoli, beef, and organ meats, supplementation may be needed to achieve significant intake levels.1,5

Studies suggest that the most potent form of lipoic acid is R-dihydrolipoic acid.1,5 In recent years it has become possible to obtain R-dihydrolipoic acid as a dietary supplement, thus providing the body with the form of lipoic acid that is most readily available to cells and tissues.

R-dihydrolipoic acid is responsible for many of the positive effects associated with lipoic acid. In the body, R-dihydrolipoic acid has immediate and significant antioxidant effects. This form of the antioxidant is particularly effective in destroying peroxynitrite free radicals, which contain both oxygen and nitrogen and have been implicated in the development of chronic inflammation, nervous system disorders, and atherosclerosis.1,5

Scientific studies showing the health benefits of lipoic acid have used doses ranging from 300 mg to 1,800 mg per day. For optimal effects, some nutritional practitioners recommend concomitantly supplementing with biotin and vitamin B complex. Lipoic acid has generally been found to be safe when administered in recommended doses. Among the rarely reported side effects in humans have been skin allergies and gastrointestinal distress.5

As lipoic acid may lower blood glucose levels, individuals with diabetes or glucose intolerance should have their blood glucose monitored while taking lipoic acid. They should also consult their physician about adjusting their dose of anti-diabetic medication in order to avoid hypoglycemia.1

Since the long-term use of lipoic acid has not yet been studied in pregnant women and nursing mothers, these individuals should avoid using the antioxidant until more information is available.1

References
1. Available at: http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/alp_0159.shtml. Accessed July 16, 2007.
2. Available at: http://lpi.oregonstate.edu/infocenter/othernuts/la/. Accessed July 16, 2007.
3. Da Ros R, Assaloni R, Ceriello A. Molecular targets of diabetic vascular complications and potential new drugs. Curr Drug Targets. 2005 Jun;6(4):503-9.
4. Ceriello A. New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care. 2003 May;26(5):1589-96.
5. No authors listed. Alpha-lipoic acid. Monograph. Altern Med Rev. 2006 Sept;11(3):232-7.
6. Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007 Mar;16(3):291-302.
7. McMackin CJ, Widlansky ME, Hamburg NM, et al. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens.(Greenwich.). 2007 Apr;9(4):249-55.
8. Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006 Oct-Dec;5(4):251-8.
9. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia. 1995 Dec;38(12):1425-33.
10. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006 Nov;29(11):2365-70.
11. Maitra I, Serbinova E, Trischler H, Packer L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radic Biol Med. 1995 Apr;18(4):823-9.
12. Filina AA, Davydova NG, Endrikhovskii SN, Shamshinova AM. Lipoic acid as a means of metabolic therapy of open-angle glaucoma. Vestn Oftalmol. 1995 Oct;111(4):6-8.
13. Komeima K, Rogers BS, Lu L, Campochiaro PA. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11300-5.
14. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78.
15. Panigrahi M, Sadguna Y, Shivakumar BR, et al. alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996 Apr 22;717(1-2):184-8.
16. Holmquist L, Stuchbury G, Berbaum K, et al. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.
17. Marracci GH, McKeon GP, Marquardt WE, et al. Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis. J Neurosci Res. 2004 Nov 1;78(3):362-70.
18. Marracci GH, Jones RE, McKeon GP, Bourdette DN. Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002 Oct;131(1-2):104-14.
19. Koh JM, Lee YS, Byun CH, et al. Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells. J Endocrinol. 2005 Jun;185(3):401-13.
20. Ha H, Lee JH, Kim HN, et al. Alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J Immunol. 2006 Jan 1;176(1):111-7.
21. Kim HJ, Chang EJ, Kim HM, et al. Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumour necrosis factor-alpha. Free Radic Biol Med. 2006 May 1;40(9):1483-93.
22. Muller L, Menzel H. Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium2+ toxicity in isolated hepatocytes. Biochim Biophys Acta. 1990 May 22;1052(3):386-91.
23. Anuradha B, Varalakshmi P. Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. Pharmacol Res. 1999 Jan;39(1):67-80.
24. Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache. 2007 Jan;47(1):52-7.
25. Beitner H. Randomized, placebo-controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003 Oct;149(4):841-9.

Details44

  • Alpha Lipoic Acid (300mg) per Capsule
  • Microcrystalline Cellulose, Di-Calcium Phosphate, Anticaking Agents (Vegetable Source Stearic Acid / Magnesium Stearate).

Details44

  • Take 1 capsule daily with food. Or as directed by your healthcare practitioner. 
  • Do not exceed the recommended intake.

Details44

  • Brand: DaVinci Labs.
  • Form: Capsules.
  • Quantity: 60.
  • Container: Plastic Tub .
  • Storage: Keep in a cool dry place, keep out of reach of children.
  • Estimated shelf life from purchase: 1 - 2 years.

Write Your Own Review

Only registered users can write reviews. Please, log in or register

Customer Reviews

Disclaimer:

The products and the claims made about specific products, articles and claims made in the articles and information written on or through this site have not been evaluated by Ancient Purity, the MHRA, the FSA or the United States FDA and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Providing a product for sale does not imply Ancient Purity recommendation of that product, its suitability or its efficacy. Ancient Purity cannot give medical opinions. No comment or entry in this site or in any communication from Ancient Purity may be taken as such.

Prices and promotions are subject to change without notice. Customers should always carefully check all the details printed on the package before opening the product. Whilst all efforts are made to ensure accuracy of description, specifications and pricing there may be occasions where errors arise. Should such a situation occur the company cannot accept your order. In the event of a mistake you will be contacted with a full explanation and a corrected offer. The information displayed is considered as an invitation to treat not as a confirmed offer for sale. The contract is confirmed upon supply of goods, Prices and promotions are subject to change without notice.

Please read the Terms and Conditions of using this site, by using the site you are accepting the terms and conditions.
All Material on this site © 2014 Ancient Purity Ltd Registered in England & Wales 07801142 VAT Reg 168 335 488